Verner-morrison-szindróma egy esete

Translated title of the contribution: Verner-Morrison syndrome: A case study

Csaba Halászlaki, Henrik Horváth, Lajos Kiss, István Takács, Gábor Speer, Zsolt Nagy, Tamás Winternitz, Gabriella Dabasi, Attila Zalatnai, Attila Patócs, Péter Lakatos

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Abstract

Verner and Morrison described a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA) in 1958. VIPomas producing high amounts of vasoactive intestinal peptide (VIP) commonly originate from the pancreas. Typical symptoms play a momentous role in the diagnosis of VIPoma. Diarrhea may persist for years before the diagnosis. Morbidity from untreated WDHA syndrome is associated with long-standing dehydration and with electrolyte and acid-base metabolism disorders, which may cause chronic renal failure. Assessment of specific marker (VIP) offers high sensitivity in establishing the diagnosis. Imaging modalities include endoscopic ultrasonography, computed tomography and magnetic resonance imaging, and particularly, scintigraphy with somatostatin analogues. Treatment options include resection of the tumor, chemotherapy or the reduction of symptoms with somatostatin analogues. Early diagnosis and management may affect survival of patients favorably. VIPoma cases may be associated with multiple endocrine neoplasia type 1.

Original languageHungarian
Pages (from-to)1111-1114
Number of pages4
JournalOrvosi hetilap
Volume151
Issue number27
DOIs
Publication statusPublished - Jul 1 2010

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Halászlaki, C., Horváth, H., Kiss, L., Takács, I., Speer, G., Nagy, Z., Winternitz, T., Dabasi, G., Zalatnai, A., Patócs, A., & Lakatos, P. (2010). Verner-morrison-szindróma egy esete. Orvosi hetilap, 151(27), 1111-1114. https://doi.org/10.1556/OH.2010.28884