Verification of skin autofluorescence values by mass spectrometry in adolescents with type 1 diabetes: Brief report

Emília Mácsai, Zoltán Takáts, László Derzbach, Anna Körner, Barna Vásárhelyi

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9 Citations (Scopus)

Abstract

Background: Accumulation of advanced glycation end products (AGEs) in tissues is a major risk factor for diabetes-associated complications. Skin autofluorescence (SAF) values measured by a specific noninvasive approach (AGE Reader; DiagnOptics Technologies B.V., Gröningen, The Netherlands) reflect the overall AGE exposure in skin. Subjects and Methods: In 16 adolescents with type 1 diabetes (age range, 11-18 years) we tested the association between SAF measured with an AGE Reader and the presence of glucuronic acid, 3-indoxyl sulfate, 3-hydroxybutyrate, phenol sulfate, and pentosidine in skin tissue determined with desorption electrospray ionization mass spectrometry (DESI-MS). These compounds are implicated in long-term diabetes complications. Results: SAF values significantly correlated with levels of compounds measured by DESI-MS (r>0.9 and P<0.001 for each). Conclusions: The strong correlation between adolescents' SAF values measured with the AGE Reader and some glycation products measured with DESI-MS indicates that SAF values may be used as surrogate markers of skin exposure to glycemic end products in type 1 diabetes.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalDiabetes Technology and Therapeutics
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 1 2013

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Medical Laboratory Technology

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