VEP and PERG in patients with multiple sclerosis, with and without a history of optic neuritis

M. Janáky, Jánossy, G. Horváth, G. Benedek, G. Braunitzer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Visual electrophysiology is routinely used to detect the visual complications of multiple sclerosis, but the analysis mostly focuses on visual evoked potential (VEP) and especially the P100 component. Our goal was to analyze the components and waveform alterations of VEPs and pattern electroretinograms (PERGs) in patients with multiple sclerosis (MS) with good vision. Methods: The main VEP and PERG components of 85 patients with MS were analyzed in two groups: 38 patients who had optic neuritis in their history (ON group) and 47 patients who had never had optic neuritis (MS group). The results were compared against a control group of 47 healthy subjects. Results: Both VEP and PERG alterations occurred in a greater number of patients than expected, and these alterations were not necessarily linked to ON in the history or a deterioration of visual acuity. Conclusions: Both VEP and PERG can detect dysfunction in the visual system in MS, even if the patient has no subjective symptoms. Even if PERG is not routinely used in neuro-ophthalmology, the results suggest that PERG assessment may provide useful information describing the retinal defect in MS.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalDocumenta Ophthalmologica
Volume134
Issue number3
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Optic Neuritis
Visual Evoked Potentials
Multiple Sclerosis
History
Electrophysiology
Ophthalmology
Visual Acuity
Healthy Volunteers
Control Groups

Keywords

  • Clinical electrophysiology
  • Multiple sclerosis
  • Neuromyelitis optica
  • Ophthalmology
  • PERG
  • VEP

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)

Cite this

VEP and PERG in patients with multiple sclerosis, with and without a history of optic neuritis. / Janáky, M.; Jánossy, ; Horváth, G.; Benedek, G.; Braunitzer, G.

In: Documenta Ophthalmologica, Vol. 134, No. 3, 01.06.2017, p. 185-193.

Research output: Contribution to journalArticle

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