Ventricular tachycardias induced by intracoronary administration of endothelin-1 in dogs

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26 Citations (Scopus)

Abstract

In 12 anesthetized, open-chest mongrel dogs, endothelin-1 (ET-1) was infused into the left anterior descending coronary artery through an indwelling catheter at a dose of 30 pmol min-1for 30 min (n = 8). In four dogs the ET-1 dose was increased to 60 pmol/min for 10 min. Programmed electrical stimulation was used for electrophysiologic studies. Coronary blood flow was reduced by 32% on average without any ischemic ECG signs. QT time (186 ± 3 ms vs. 218 ± 6, p < 0.05, and 225 ± 9, p < 0.05, p < 0.05). Ventricular irritability increased in all cases; ventricular extrasystoles, and nonsustained and sustained tachycardias occurred and, in 11 cases, ventricular fibrillation terminated the experiments. In two dogs, early after depolarization was recorded. Therefore, ET-1 is capable of inducing fatal ventricular arrythmias at least partly independent of its vasoconstrictor effect. QT prolongation appears to have a pathophysiologic role in this arrythmogenic effect.

Original languageEnglish
Pages (from-to)S153-S155
JournalJournal of cardiovascular pharmacology
Volume26
DOIs
Publication statusPublished - 1995

Keywords

  • Coronary blood flow
  • Dogs
  • Electrophysiologic studies
  • Endothelin-1
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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