Venous thromboembolism and subsequent diagnosis of subarachnoid hemorrhage: A 20-year cohort study

H. T. Sørensen, E. Puhó, S. Christensen, L. Pedersen, P. Prandoni, J. A. Baron

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Venous thromboembolism is a predictor of subsequent risk of ischemic stroke and intracerebral hemorrhage, but no data are available regarding its association with risk of subarachnoid hemorrhage. Objectives: To examine this issue, we conducted a nationwide cohort study in Denmark. Patients and methods: Between 1977 and 2007, we identified 97 558 patients with a hospital diagnosis of venous thromboembolism and obtained information on risk of subsequent subarachnoid hemorrhage during follow-up in the Danish Registry of Patients. The incidence of subarachnoid hemorrhage in the venous thromboembolism cohort was compared with that of 453 406 population control cohort members. Results: For patients with pulmonary embolism (PE), there was clearly an increased risk of subarachnoid hemorrhage, both during the first year of follow-up [relative risk 2.69; 95% confidence interval (CI), 1.32-5.48] and during later follow-up of 2-20 years (relative risk 1.40; 95% CI, 1.05-1.87). For patients with deep venous thrombosis (DVT) the risk was likewise clearly increased during the first year of follow-up (relative risk 1.91; 95% CI, 1.13-3.22), but not during later follow-up (relative risk 1.04; 95% CI, 0.81-1.32). Conclusions: We found evidence that PE is associated with an increased long-term risk of subarachnoid hemorrhage. The two diseases might share etiologic pathways affecting the vessel wall or share unknown risk factors.

Original languageEnglish
Pages (from-to)1710-1715
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Venous Thromboembolism
Subarachnoid Hemorrhage
Cohort Studies
Confidence Intervals
Pulmonary Embolism
Population Control
Cerebral Hemorrhage
Denmark
Venous Thrombosis
Registries
Stroke
Incidence

Keywords

  • Epidemiology
  • Risk
  • Subarachnoid hemorrhage
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Cite this

Venous thromboembolism and subsequent diagnosis of subarachnoid hemorrhage : A 20-year cohort study. / Sørensen, H. T.; Puhó, E.; Christensen, S.; Pedersen, L.; Prandoni, P.; Baron, J. A.

In: Journal of Thrombosis and Haemostasis, Vol. 8, No. 8, 08.2010, p. 1710-1715.

Research output: Contribution to journalArticle

Sørensen, H. T. ; Puhó, E. ; Christensen, S. ; Pedersen, L. ; Prandoni, P. ; Baron, J. A. / Venous thromboembolism and subsequent diagnosis of subarachnoid hemorrhage : A 20-year cohort study. In: Journal of Thrombosis and Haemostasis. 2010 ; Vol. 8, No. 8. pp. 1710-1715.
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