Vasopressin signaling at brain level controls stress hormone release: The vasopressin-deficient Brattleboro rat as a model

Dóra Zelena, Ottó Pintér, Diána Gabriella Balázsfi, Kristina Langnaese, Karin Richter, Rainer Landgraf, Gábor B. Makara, Mario Engelmann

Research output: Contribution to journalReview article

9 Citations (Scopus)


The nonapeptide arginine vasopressin (AVP) has long been suggested to play an important role as a secretagogue for triggering the activity of the endocrine stress response. Most recent studies employed mutant mice for analyzing the importance of AVP for endocrine regulation under stress. However, it is difficult to compare and draw overall conclusions from all these studies as mixing the genetic material from different mouse strains has consequences on the individual's stress response. Moreover, mice are not ideal subjects for several experimental procedures. Therefore, to get more insight, we used a rather old mutant rat model: the AVP-deficient Brattleboro rat. The present short review is aimed at providing the most interesting results of these studies within the last 8 years that allowed gaining new insights in the potential signal function of AVP in stress and endocrine regulation.

Original languageEnglish
Pages (from-to)2245-2253
Number of pages9
JournalAmino Acids
Issue number11
Publication statusPublished - Nov 1 2015



  • AVP
  • Brattleboro rat
  • HPA axis
  • Hormone
  • Stress
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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