Vasopressin receptor antagonist OPC-31260 prevents cerebral oedema after subarachnoid haemorrhage

F. László, C. Varga, Shigeki Nakamura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of the non-peptide vasopressin V2 receptor antagonist, 5-dimethylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (OPC-31260) on the cerebral oedema induced by subarachnoid haemorrhage were studied in rats. Subarachnoid haemorrhage induced significant water retention after water loading, increased the brain content of water and Na+ and increased plasma vasopressin levels. The water retention and brain water and Na+ accumulation were prevented by OPC-31260 administration, but the plasma vasopressin levels were further enhanced by OPC-31260. These results demonstrate the important role of vasopressin in the development of antidiuresis and disturbances in brain water and electrolyte balance in response to subarachnoid haemorrhage. The subarachnoid haemorrhage-induced cerebral oedema was significantly reduced following oral OPC-31260 administration. The protective mechanism exerted by OPC-31260 stems from its influence on renal tubular function: it blocks the renal vasopressin V2 receptors. These observations might suggest a new, effective approach to the treatment of subarachnoid haemorrhage-induced cerebral oedema in humans. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalEuropean Journal of Pharmacology
Volume364
Issue number2-3
DOIs
Publication statusPublished - Jan 8 1999

Fingerprint

Brain Edema
Subarachnoid Hemorrhage
Vasopressins
Water
Vasopressin Receptors
Brain
Kidney
Water-Electrolyte Balance
mozavaptan
Antidiuretic Hormone Receptor Antagonists

Keywords

  • Cerebral oedema
  • Non-peptide
  • Subarachnoid haemorrhage
  • Vasopressin receptor antagonist

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Vasopressin receptor antagonist OPC-31260 prevents cerebral oedema after subarachnoid haemorrhage. / László, F.; Varga, C.; Nakamura, Shigeki.

In: European Journal of Pharmacology, Vol. 364, No. 2-3, 08.01.1999, p. 115-122.

Research output: Contribution to journalArticle

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