Vasopressin entry into the inner ear fluids of the rat

I. Sziklai, Evelyne Ferrary, Olivier Sterkers, Claude Amiel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The entry of arginine-vasopressin (AVP) and sucrose into cochlear endolymph, perilymph of scala vestibuli (PLV), perilymph of scala tympani (PLT), and cisternal cerebrospinal fluid (CSF) was studied, in anesthetized rats, after the administration into the cerebral lateral ventricle of a 10μ1 solution containing the radioactive tracers. Both tracers were detected in PLV, PLT, and CSF but not in endolymph. Monoexponential decay curves were calculated for PLV, PLT, and CSF, and for each tracer no difference was found between the regression lines calculated for the different fluids. These results indicate that (i) injection into the cerebral lateral ventricle is a useful tool to study the permeability of the cochlear epithelium to different solutes and (ii) no specific transport system exists for AVP across the cochlear epithelium, suggesting that AVP may exert its effect via the perilymphatic side of the stria vascularis.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalHearing Research
Volume29
Issue number2-3
DOIs
Publication statusPublished - 1987

Fingerprint

Perilymph
Inner Ear
Vasopressins
Scala Vestibuli
Scala Tympani
Arginine Vasopressin
Cochlea
Endolymph
Cerebrospinal Fluid
Cerebral Ventricles
Lateral Ventricles
Epithelium
Stria Vascularis
Radioactive Tracers
Sucrose
Permeability
Injections

Keywords

  • Cerebral lateral ventricle
  • Endolymph
  • Perilymph
  • Sucrose
  • Vasopressin

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Vasopressin entry into the inner ear fluids of the rat. / Sziklai, I.; Ferrary, Evelyne; Sterkers, Olivier; Amiel, Claude.

In: Hearing Research, Vol. 29, No. 2-3, 1987, p. 245-250.

Research output: Contribution to journalArticle

Sziklai, I. ; Ferrary, Evelyne ; Sterkers, Olivier ; Amiel, Claude. / Vasopressin entry into the inner ear fluids of the rat. In: Hearing Research. 1987 ; Vol. 29, No. 2-3. pp. 245-250.
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