Vasopressin deficiency decreases the frequency of gastroduodenal ulceration in humans

Imre Pávó, E. Morschl, Zoltán Szepes, József Kiss, K. Boda, Gábor Vetró, C. Varga, F. László, F. László

Research output: Contribution to journalArticle

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Abstract

Vasopressin is a stress hormone released from the posterior pituitary. In humans suffering from central diabetes insipidus, this release of vasopressin is diminished. It was shown previously that the congenutally vasopressin-deficient Brattleboro homozygous rat is less sensitive to various ulcerogenic stimuli. In this study, we investigated the incidence of gastroduodenal ulceration in vasopressin deficient patients. Data on patients aged 20-70, hospitalized in Hungary between 1992 and 1995 were compared with those on the total population in this age group (6 681 020 in 1994). Subjects with central diabetes insipidus were selected separately (815 cases). Gastroduodenal ulceration was compared in subjects with an intact vasopressin release and vasopressin-deficient patients. The frequencies of gastroduodenal ulceration were also examined separately in male and female subjects. In the total population, the frequency of gastroduodenal ulceration was lower in vasopressin-deficient cases (2.22% versus 0.61%; P <0.005). Among normal- vasopressin subjects, males have a higher risk of gastroduodenal ulceration than females (3.04% versus 1.46%, respectively; P <0.001). Among vasopressin-deficient subjects, a similar male:female ratio was observed, but it was not significant (P = 0.36). In comparison to the normal-vasopressin population, the incidence of gastroduodenal ulceration was reduced among vasopressin-deficient males and females by 77% (P <0.01) and by 82% (P <0.05), respectively. In conclusion, endogenous vasopressin has a significant harmful action towards the human gastroduodenal mucosa. Peptide and non- peptide vasopressin receptor antagonists might have a potential therapeutic benefit in the treatment (as an adjuvant) and prevention of gastroduodenal ulceration. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalJournal of Physiology Paris
Volume94
Issue number1
DOIs
Publication statusPublished - Jan 2000

Fingerprint

Neurogenic Diabetes Insipidus
Vasopressins
Brattleboro Rats
Posterior Pituitary Hormones
Population
Peptide Receptors
Hungary
Incidence

Keywords

  • Diabetes insipidus
  • Duodenal ulcer
  • Gastric ulcer
  • Ulcer disease
  • Vasopressin
  • Vasopressin receptor antagonist

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Vasopressin deficiency decreases the frequency of gastroduodenal ulceration in humans. / Pávó, Imre; Morschl, E.; Szepes, Zoltán; Kiss, József; Boda, K.; Vetró, Gábor; Varga, C.; László, F.; László, F.

In: Journal of Physiology Paris, Vol. 94, No. 1, 01.2000, p. 63-66.

Research output: Contribution to journalArticle

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abstract = "Vasopressin is a stress hormone released from the posterior pituitary. In humans suffering from central diabetes insipidus, this release of vasopressin is diminished. It was shown previously that the congenutally vasopressin-deficient Brattleboro homozygous rat is less sensitive to various ulcerogenic stimuli. In this study, we investigated the incidence of gastroduodenal ulceration in vasopressin deficient patients. Data on patients aged 20-70, hospitalized in Hungary between 1992 and 1995 were compared with those on the total population in this age group (6 681 020 in 1994). Subjects with central diabetes insipidus were selected separately (815 cases). Gastroduodenal ulceration was compared in subjects with an intact vasopressin release and vasopressin-deficient patients. The frequencies of gastroduodenal ulceration were also examined separately in male and female subjects. In the total population, the frequency of gastroduodenal ulceration was lower in vasopressin-deficient cases (2.22{\%} versus 0.61{\%}; P <0.005). Among normal- vasopressin subjects, males have a higher risk of gastroduodenal ulceration than females (3.04{\%} versus 1.46{\%}, respectively; P <0.001). Among vasopressin-deficient subjects, a similar male:female ratio was observed, but it was not significant (P = 0.36). In comparison to the normal-vasopressin population, the incidence of gastroduodenal ulceration was reduced among vasopressin-deficient males and females by 77{\%} (P <0.01) and by 82{\%} (P <0.05), respectively. In conclusion, endogenous vasopressin has a significant harmful action towards the human gastroduodenal mucosa. Peptide and non- peptide vasopressin receptor antagonists might have a potential therapeutic benefit in the treatment (as an adjuvant) and prevention of gastroduodenal ulceration. (C) 2000 Elsevier Science Ltd.",
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