Vasectomy modulates the local effect of intratesticular opioids on the gonad of immature rats

I. Gerendai, A. Nemeskeri, V. Csernus

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Previous studies indicate that 7 days after testicular administration of naloxone, serum testosterone (T) concentration and basal T secretion in vitro decrease significantly. In neonatal rats, short-term (2 h) intratesticular treatment with 0.3 μg (D-Met2-Pro5)-enkephalinamide suppresses steroidogenesis. In the present study, testicular treatment with naloxone or enkephalinamide was combined with hemivasectomy (which also includes transection of the inferior spermatic nerve). When local treatment with naloxone was combined with vasectomy in 15-day-old rats, the opioid antagonist-induced increase in testicular weight, the decrease in basal T secretion of the treated gonad and the drop in serum T level could not be observed 7 days postsurgery, despite the fact that in immature rats, hemivasectomy, by itself, also reduces steroid secretion. Similarly, in 5-day-old animals, the short-term (2 h) effect of testicular enkephalinamide on T secretion was prevented by vasectomy. These data suggest that local testicular actions exerted by endogenous opioid peptides might be modulated by the inferior spermatic nerve.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalNeuroendocrinology
Volume56
Issue number3
Publication statusPublished - 1992

Fingerprint

Vasectomy
Gonads
Naloxone
Opioid Analgesics
Spermatozoa
Opioid Peptides
Narcotic Antagonists
Serum
Testosterone
Therapeutics
Steroids
Weights and Measures

Keywords

  • Enkephalinamide
  • Naloxone
  • Testis
  • Testosterone
  • Vasectomy

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Vasectomy modulates the local effect of intratesticular opioids on the gonad of immature rats. / Gerendai, I.; Nemeskeri, A.; Csernus, V.

In: Neuroendocrinology, Vol. 56, No. 3, 1992, p. 295-299.

Research output: Contribution to journalArticle

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