Vascular Network Formation in Expanding versus Static Tissues: Embryos and Tumors

A. Czirók, Brenda J. Rongish, Charles D. Little

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this perspectives article, we review scientific literature regarding de novo formation of vascular networks within tissues undergoing a significant degree of motion. Next, we contrast dynamic pattern formation in embryos to the vascularization of relatively static tissues, such as the retina. We argue that formation of primary polygonal vascular networks is an emergent process, which is regulated by biophysical mechanisms. Dynamic empirical data, derived from quail embryos, show that vascular beds readily form within a moving extracellular matrix (ECM) microenvironment-which we analogize to the de novo vascularization of small rapidly growing tumors. Our perspective is that the biophysical rules, which govern cell motion during vasculogenesis, may hold important clues to understanding how the first vessels form in certain malignancies.

Original languageEnglish
Pages (from-to)1072-1080
Number of pages9
JournalGenes and Cancer
Volume2
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Blood Vessels
Embryonic Structures
Neoplasms
Quail
Extracellular Matrix
Retina

Keywords

  • cell motility
  • multicellular sprouting
  • tissue movements
  • vascular patterning

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Vascular Network Formation in Expanding versus Static Tissues : Embryos and Tumors. / Czirók, A.; Rongish, Brenda J.; Little, Charles D.

In: Genes and Cancer, Vol. 2, No. 12, 12.2011, p. 1072-1080.

Research output: Contribution to journalArticle

Czirók, A. ; Rongish, Brenda J. ; Little, Charles D. / Vascular Network Formation in Expanding versus Static Tissues : Embryos and Tumors. In: Genes and Cancer. 2011 ; Vol. 2, No. 12. pp. 1072-1080.
@article{84036f7e3b08495988aa60a297e6fb78,
title = "Vascular Network Formation in Expanding versus Static Tissues: Embryos and Tumors",
abstract = "In this perspectives article, we review scientific literature regarding de novo formation of vascular networks within tissues undergoing a significant degree of motion. Next, we contrast dynamic pattern formation in embryos to the vascularization of relatively static tissues, such as the retina. We argue that formation of primary polygonal vascular networks is an emergent process, which is regulated by biophysical mechanisms. Dynamic empirical data, derived from quail embryos, show that vascular beds readily form within a moving extracellular matrix (ECM) microenvironment-which we analogize to the de novo vascularization of small rapidly growing tumors. Our perspective is that the biophysical rules, which govern cell motion during vasculogenesis, may hold important clues to understanding how the first vessels form in certain malignancies.",
keywords = "cell motility, multicellular sprouting, tissue movements, vascular patterning",
author = "A. Czir{\'o}k and Rongish, {Brenda J.} and Little, {Charles D.}",
year = "2011",
month = "12",
doi = "10.1177/1947601911426774",
language = "English",
volume = "2",
pages = "1072--1080",
journal = "Genes and Cancer",
issn = "1947-6019",
publisher = "SAGE Publications Inc.",
number = "12",

}

TY - JOUR

T1 - Vascular Network Formation in Expanding versus Static Tissues

T2 - Embryos and Tumors

AU - Czirók, A.

AU - Rongish, Brenda J.

AU - Little, Charles D.

PY - 2011/12

Y1 - 2011/12

N2 - In this perspectives article, we review scientific literature regarding de novo formation of vascular networks within tissues undergoing a significant degree of motion. Next, we contrast dynamic pattern formation in embryos to the vascularization of relatively static tissues, such as the retina. We argue that formation of primary polygonal vascular networks is an emergent process, which is regulated by biophysical mechanisms. Dynamic empirical data, derived from quail embryos, show that vascular beds readily form within a moving extracellular matrix (ECM) microenvironment-which we analogize to the de novo vascularization of small rapidly growing tumors. Our perspective is that the biophysical rules, which govern cell motion during vasculogenesis, may hold important clues to understanding how the first vessels form in certain malignancies.

AB - In this perspectives article, we review scientific literature regarding de novo formation of vascular networks within tissues undergoing a significant degree of motion. Next, we contrast dynamic pattern formation in embryos to the vascularization of relatively static tissues, such as the retina. We argue that formation of primary polygonal vascular networks is an emergent process, which is regulated by biophysical mechanisms. Dynamic empirical data, derived from quail embryos, show that vascular beds readily form within a moving extracellular matrix (ECM) microenvironment-which we analogize to the de novo vascularization of small rapidly growing tumors. Our perspective is that the biophysical rules, which govern cell motion during vasculogenesis, may hold important clues to understanding how the first vessels form in certain malignancies.

KW - cell motility

KW - multicellular sprouting

KW - tissue movements

KW - vascular patterning

UR - http://www.scopus.com/inward/record.url?scp=84868624160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868624160&partnerID=8YFLogxK

U2 - 10.1177/1947601911426774

DO - 10.1177/1947601911426774

M3 - Article

C2 - 22866198

AN - SCOPUS:84868624160

VL - 2

SP - 1072

EP - 1080

JO - Genes and Cancer

JF - Genes and Cancer

SN - 1947-6019

IS - 12

ER -