Vascular memory: Can we broaden the concept of the metabolic memory?

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Based on the results of recent randomized, controlled clinical trials and analyses of their follow-up periods the concept of metabolic memory cannot be restricted to antihyperglycaemic treatment only, rather it can be extended to lipid-lowering and antihypertensive treatment and even life-style modification. This broadened concept can be designated as vascular memory. According to this new concept, not only immediate and short-term but long-term effects of the metabolic and cardiovascular risk milieu are of great importance. Consequently, early and intensive lifestyle interventions, treatment of hyperglycaemia, lipid abnormalities and hypertension can result in beneficial effects on cardiovascular outcomes even in the long run. On the contrary, failing in target-oriented treatment from early detection of abnormalities can be associated with life-threatening cardiovascular events subsequently. Additional experimental studies are needed to characterize the exact pathomechanism of vascular memory and further clinical trials are also essential to explore its real clinical significance.

Original languageEnglish
Article number44
JournalCardiovascular Diabetology
Volume11
DOIs
Publication statusPublished - Apr 30 2012

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Blood Vessels
Life Style
Lipids
Hypoglycemic Agents
Hyperglycemia
Antihypertensive Agents
Randomized Controlled Trials
Clinical Trials
Hypertension

Keywords

  • Cardiovascular diseases
  • Metabolic legacy
  • Metabolic memory
  • Vascular memory

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Vascular memory : Can we broaden the concept of the metabolic memory? / Jermendy, G.

In: Cardiovascular Diabetology, Vol. 11, 44, 30.04.2012.

Research output: Contribution to journalArticle

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