Vascular endothelium and immune responses: Implications for inflammation and angiogenesis

Z. Szekanecz, Alisa E. Koch

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Endothelial cells (ECs) are involved in several mechanisms during the immune response, particularly in inflammation. Leukocyte-EC adhesion is regulated by the interactions of receptor-ligand adhesion molecule pairs, as well as by soluble mediators, such as proinflammatory cytokines. ECs are active participants in new vessel formation termed "angiogenesis." There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms described above. Specific targeting of pathologic endothelial function may be useful for the future management of various inflammatory diseases.

Original languageEnglish
Pages (from-to)97-114
Number of pages18
JournalRheumatic Disease Clinics of North America
Volume30
Issue number1
DOIs
Publication statusPublished - Feb 2004

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Vascular Endothelium
Endothelial Cells
Inflammation
Cell Adhesion
Leukocytes
Cytokines
Ligands

ASJC Scopus subject areas

  • Rheumatology

Cite this

Vascular endothelium and immune responses : Implications for inflammation and angiogenesis. / Szekanecz, Z.; Koch, Alisa E.

In: Rheumatic Disease Clinics of North America, Vol. 30, No. 1, 02.2004, p. 97-114.

Research output: Contribution to journalArticle

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