Vascular endothelial growth factor polymorphisms in mantle cell lymphoma

S. Galimberti, B. Nagy, G. A. Palumbo, E. Ciancia, G. Buda, E. Orciuolo, A. Melosi, P. Lambelet, F. Ronca, M. Petrini

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13 Citations (Scopus)

Abstract

In this study, we determined the allele and genotype frequencies of vascular endothelial growth factor (VEGF) G+405C, C-460T, C+936T and C-2578A single nucleotide polymorphisms (SNPs) in 32 patients affected by mantle cell lymphoma (MCL) and 58 healthy controls. Real-time PCR combined with melting curve analysis was used for the determination of SNP alleles. A significant difference in the allele frequency of VEGFC-460T and C+936T SNPs in MCL and healthy cases was not observed. On the contrary, VEGF G+405C and C-2578A SNP allele distribution was significantly lower in the patient group than among normal controls (p = 0.014, p = 0.001). This observation suggests that further investigation is warranted, both in vitro and in a larger series of patients, to further examine the role of VEGF polymorphisms in the pathogenesis of MCL. In addition, the use of quantitative real-time PCR combined with a melting curve analysis method in the detection of the 4 VEGF SNPs may have the potential to replace older and more time-consuming PCR-RFLP methods and bears further investigation.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalActa Haematologica
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

Keywords

  • Mantle cell lymphoma
  • Polymorphism
  • Single nucleotide polymorphism
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Galimberti, S., Nagy, B., Palumbo, G. A., Ciancia, E., Buda, G., Orciuolo, E., Melosi, A., Lambelet, P., Ronca, F., & Petrini, M. (2010). Vascular endothelial growth factor polymorphisms in mantle cell lymphoma. Acta Haematologica, 123(2), 91-95. https://doi.org/10.1159/000267826