Vascular endothelial growth factor polymorphisms in mantle cell lymphoma

S. Galimberti, B. Nagy, G. A. Palumbo, E. Ciancia, G. Buda, E. Orciuolo, A. Melosi, P. Lambelet, F. Ronca, M. Petrini

Research output: Contribution to journalArticle

13 Citations (Scopus)


In this study, we determined the allele and genotype frequencies of vascular endothelial growth factor (VEGF) G+405C, C-460T, C+936T and C-2578A single nucleotide polymorphisms (SNPs) in 32 patients affected by mantle cell lymphoma (MCL) and 58 healthy controls. Real-time PCR combined with melting curve analysis was used for the determination of SNP alleles. A significant difference in the allele frequency of VEGFC-460T and C+936T SNPs in MCL and healthy cases was not observed. On the contrary, VEGF G+405C and C-2578A SNP allele distribution was significantly lower in the patient group than among normal controls (p = 0.014, p = 0.001). This observation suggests that further investigation is warranted, both in vitro and in a larger series of patients, to further examine the role of VEGF polymorphisms in the pathogenesis of MCL. In addition, the use of quantitative real-time PCR combined with a melting curve analysis method in the detection of the 4 VEGF SNPs may have the potential to replace older and more time-consuming PCR-RFLP methods and bears further investigation.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalActa Haematologica
Issue number2
Publication statusPublished - Feb 1 2010


  • Mantle cell lymphoma
  • Polymorphism
  • Single nucleotide polymorphism
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Vascular endothelial growth factor polymorphisms in mantle cell lymphoma'. Together they form a unique fingerprint.

  • Cite this

    Galimberti, S., Nagy, B., Palumbo, G. A., Ciancia, E., Buda, G., Orciuolo, E., Melosi, A., Lambelet, P., Ronca, F., & Petrini, M. (2010). Vascular endothelial growth factor polymorphisms in mantle cell lymphoma. Acta Haematologica, 123(2), 91-95.