Vascular endothelial growth factor levels in tears of patients with retinal vein occlusion

M. Kasza, Z. Balogh, L. Biro, B. Ujhelyi, J. Damjanovich, A. Csutak, J. Várdai, A. Berta, V. Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)


Purpose: We measured vascular endothelial growth factor (VEGF) levels in tear fluid and serum in patients with retinal vein occlusion (RVO). Patients and methods: Eight patients with RVO due to secondary macular oedema were examined. VEGF levels were measured by enzyme-linked immunosorbent assay. All patients had a full ophthalmic examination (visual acuity, slit lamp biomicroscopy, perimetry, and fluorescein angiography). Central retinal thickness (CRT) was examined using optical coherence tomography (OCT). Tear and serum samples were collected and examinations were performed at diagnosis and 1 and 4 weeks later. Results: VEGF levels in the tears of RVO eyes were significantly higher than in fellow eyes at diagnosis and after both 1 and 4 weeks (paired t test, p1 = 0.01, p2 = 0.02, p3 = 0.006). We found a weak but significant positive correlation between VEGF levels in tear fluid and serum of patients with RVO (r = 0.21), while this correlation tended to be stronger between the fellow eyes and serum levels (r = 0.33). Conclusion: To the best of our knowledge, we are the first to report an increased level of VEGF in the tear fluid of patients with RVO. Alterations of VEGF levels in tears may be useful for determining stages of RVO. This non-invasive and objective method may also be helpful for estimating the severity of macular oedema and efficacy of treatment.

Original languageEnglish
Pages (from-to)1581-1586
Number of pages6
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number9
Publication statusPublished - Sep 26 2015


  • Central retinal thickness (CRT)
  • Retinal vein occlusion (RVO)
  • Tear fluid
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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