Vascular changes play a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs

B. Gellén, J. Kovács, L. Németh, P. Németh, J. Vágvölgyi, F. Bari, P. Megyeri, S. Pintér, P. Temesvári, M. Deli, M. Vecsernyés, Z. Szilvássy, M. Koltai, C. Ábrahám

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Necrotizing enterocolitis (NEC) is the most common acquired gastrointestinal emergency in neonates. We have developed an animal model of NEC in asphyxiated newborn pigs and investigated the effects of asphyxia on blood flow in superior mesenteric artery and abdominal aorta, cardiovascular data, arterial acid-base and blood gas parameters, and endothelial cytoskeletal structure in mesenteric microvasculature. Anesthetized, mechanically ventilated newborn pigs were included in two groups: piglets underwent severe asphyxia, and sham-operated control animals. A cardiovascular and metabolic failure developed in asphyxiated piglets approximately 1 h after the induction: severe hypotension and bradyarrhythmia were seen and significant reductions of the blood flow were measured in the superior mesenteric artery and abdominal aorta during the critical phase. Rearrangement of cytoskeletal actin structure corresponding to enhanced vascular permeability was seen with bodipy phallacidin in mesenterial endothelium of asphyxiated piglets after a 24-h recovery period. In conclusion, severe vasomotor changes during asphyxia may result in mesenteric endothelial dysfunction implicated in increased vascular permeability, edema formation, and development of NEC in asphyxiated piglets.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalPediatric Surgery International
Volume19
Issue number5
DOIs
Publication statusPublished - Jul 2003

Fingerprint

Necrotizing Enterocolitis
Asphyxia
Blood Vessels
Superior Mesenteric Artery
Swine
Abdominal Aorta
Capillary Permeability
Bradycardia
Microvessels
Hypotension
Endothelium
Actins
Edema
Emergencies
Animal Models
Gases
Acids

Keywords

  • Asphyxia
  • Necrotizing enterocolitis
  • Porcine model
  • Vascular changes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vascular changes play a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs. / Gellén, B.; Kovács, J.; Németh, L.; Németh, P.; Vágvölgyi, J.; Bari, F.; Megyeri, P.; Pintér, S.; Temesvári, P.; Deli, M.; Vecsernyés, M.; Szilvássy, Z.; Koltai, M.; Ábrahám, C.

In: Pediatric Surgery International, Vol. 19, No. 5, 07.2003, p. 380-384.

Research output: Contribution to journalArticle

Gellén, B. ; Kovács, J. ; Németh, L. ; Németh, P. ; Vágvölgyi, J. ; Bari, F. ; Megyeri, P. ; Pintér, S. ; Temesvári, P. ; Deli, M. ; Vecsernyés, M. ; Szilvássy, Z. ; Koltai, M. ; Ábrahám, C. / Vascular changes play a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs. In: Pediatric Surgery International. 2003 ; Vol. 19, No. 5. pp. 380-384.
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