Vascular biomechan1cs in hypertensive and diabetic rats

M. Szentivanvi, G. L. Nàdasv, L. A. Sarmai, V. Kopcsânyi, A. Jednàkovits, E. Monos

Research output: Contribution to journalArticle

Abstract

Biomechanical properties of saphenous vessels in "multiple risk factor" conditions were studied. Spontaneously hypertensive (SHR), streptozotocin (STZ, 40 mg/kg) induced diabetic SHR (SHR-STZ), and normal Wistar-Kyoto (WKY) rats of the same age were compared in vitro Intraluminal pressure (IPJ-diameter plots for resting, methoxamine (1 6x10"s mol/1) contracted and papaverine (2 8xl04 mol/1) relaxed segments were recorded Saphenous arteries of SHRSTZ showed larger contractile response, than those of SHR and WKY (act strain, at 100 mmHg IP: 10.03±2.70 vs. 7.12±4.1 vs. 0.35±0.46 %). Due to the enhanced smooth muscle tone distensibility and elastic modulus curves of SHR were shifted toward elastic direction but at in vivo pressure levels there was no difference in these parameters Diabetes caused arterial wall stiffening (distensibility, at 100 mmHg: 2.210.4 vs. 3.4+0.4x10-6 cm2/dyne). Although wall thickness and external radius of the SHR-STZ rats were decreased, lumen capacity of the three groups was not different. Saphenous vein of the SHR showed larger lumen capacity than veins of SHR-STZ and WKY (lumen capacity, at 8 mmHg IP 0.43 ±0.04 vs. 0.29 ±0.04 vs. 0.27±0 02 mm3/mm), but elastic and contractile parameters did not exhibit significant differences. We conclude that arterial responsiveness and venous capacity function are enhanced in hypertension, while diabetes causes arterial wall stiffening and decreased venous capacity in rats. Supported by grants ETT No. 291 93/94, OTKA No. T017789, and BIOREX Res & Dev Co.

Original languageEnglish
JournalFASEB Journal
Volume10
Issue number3
Publication statusPublished - 1996

Fingerprint

blood vessels
Blood Vessels
Rats
Medical problems
Methoxamine
Pressure
Papaverine
diabetes
Inbred WKY Rats
Organized Financing
Elastic Modulus
rats
Saphenous Vein
Inbred SHR Rats
Streptozocin
saphenous vein
papaverine
Smooth Muscle
Veins
Arteries

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Szentivanvi, M., Nàdasv, G. L., Sarmai, L. A., Kopcsânyi, V., Jednàkovits, A., & Monos, E. (1996). Vascular biomechan1cs in hypertensive and diabetic rats. FASEB Journal, 10(3).

Vascular biomechan1cs in hypertensive and diabetic rats. / Szentivanvi, M.; Nàdasv, G. L.; Sarmai, L. A.; Kopcsânyi, V.; Jednàkovits, A.; Monos, E.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Szentivanvi, M, Nàdasv, GL, Sarmai, LA, Kopcsânyi, V, Jednàkovits, A & Monos, E 1996, 'Vascular biomechan1cs in hypertensive and diabetic rats', FASEB Journal, vol. 10, no. 3.
Szentivanvi M, Nàdasv GL, Sarmai LA, Kopcsânyi V, Jednàkovits A, Monos E. Vascular biomechan1cs in hypertensive and diabetic rats. FASEB Journal. 1996;10(3).
Szentivanvi, M. ; Nàdasv, G. L. ; Sarmai, L. A. ; Kopcsânyi, V. ; Jednàkovits, A. ; Monos, E. / Vascular biomechan1cs in hypertensive and diabetic rats. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
@article{5b4901c371144322bdd03343896a3599,
title = "Vascular biomechan1cs in hypertensive and diabetic rats",
abstract = "Biomechanical properties of saphenous vessels in {"}multiple risk factor{"} conditions were studied. Spontaneously hypertensive (SHR), streptozotocin (STZ, 40 mg/kg) induced diabetic SHR (SHR-STZ), and normal Wistar-Kyoto (WKY) rats of the same age were compared in vitro Intraluminal pressure (IPJ-diameter plots for resting, methoxamine (1 6x10{"}s mol/1) contracted and papaverine (2 8xl04 mol/1) relaxed segments were recorded Saphenous arteries of SHRSTZ showed larger contractile response, than those of SHR and WKY (act strain, at 100 mmHg IP: 10.03±2.70 vs. 7.12±4.1 vs. 0.35±0.46 {\%}). Due to the enhanced smooth muscle tone distensibility and elastic modulus curves of SHR were shifted toward elastic direction but at in vivo pressure levels there was no difference in these parameters Diabetes caused arterial wall stiffening (distensibility, at 100 mmHg: 2.210.4 vs. 3.4+0.4x10-6 cm2/dyne). Although wall thickness and external radius of the SHR-STZ rats were decreased, lumen capacity of the three groups was not different. Saphenous vein of the SHR showed larger lumen capacity than veins of SHR-STZ and WKY (lumen capacity, at 8 mmHg IP 0.43 ±0.04 vs. 0.29 ±0.04 vs. 0.27±0 02 mm3/mm), but elastic and contractile parameters did not exhibit significant differences. We conclude that arterial responsiveness and venous capacity function are enhanced in hypertension, while diabetes causes arterial wall stiffening and decreased venous capacity in rats. Supported by grants ETT No. 291 93/94, OTKA No. T017789, and BIOREX Res & Dev Co.",
author = "M. Szentivanvi and N{\`a}dasv, {G. L.} and Sarmai, {L. A.} and V. Kopcs{\^a}nyi and A. Jedn{\`a}kovits and E. Monos",
year = "1996",
language = "English",
volume = "10",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Vascular biomechan1cs in hypertensive and diabetic rats

AU - Szentivanvi, M.

AU - Nàdasv, G. L.

AU - Sarmai, L. A.

AU - Kopcsânyi, V.

AU - Jednàkovits, A.

AU - Monos, E.

PY - 1996

Y1 - 1996

N2 - Biomechanical properties of saphenous vessels in "multiple risk factor" conditions were studied. Spontaneously hypertensive (SHR), streptozotocin (STZ, 40 mg/kg) induced diabetic SHR (SHR-STZ), and normal Wistar-Kyoto (WKY) rats of the same age were compared in vitro Intraluminal pressure (IPJ-diameter plots for resting, methoxamine (1 6x10"s mol/1) contracted and papaverine (2 8xl04 mol/1) relaxed segments were recorded Saphenous arteries of SHRSTZ showed larger contractile response, than those of SHR and WKY (act strain, at 100 mmHg IP: 10.03±2.70 vs. 7.12±4.1 vs. 0.35±0.46 %). Due to the enhanced smooth muscle tone distensibility and elastic modulus curves of SHR were shifted toward elastic direction but at in vivo pressure levels there was no difference in these parameters Diabetes caused arterial wall stiffening (distensibility, at 100 mmHg: 2.210.4 vs. 3.4+0.4x10-6 cm2/dyne). Although wall thickness and external radius of the SHR-STZ rats were decreased, lumen capacity of the three groups was not different. Saphenous vein of the SHR showed larger lumen capacity than veins of SHR-STZ and WKY (lumen capacity, at 8 mmHg IP 0.43 ±0.04 vs. 0.29 ±0.04 vs. 0.27±0 02 mm3/mm), but elastic and contractile parameters did not exhibit significant differences. We conclude that arterial responsiveness and venous capacity function are enhanced in hypertension, while diabetes causes arterial wall stiffening and decreased venous capacity in rats. Supported by grants ETT No. 291 93/94, OTKA No. T017789, and BIOREX Res & Dev Co.

AB - Biomechanical properties of saphenous vessels in "multiple risk factor" conditions were studied. Spontaneously hypertensive (SHR), streptozotocin (STZ, 40 mg/kg) induced diabetic SHR (SHR-STZ), and normal Wistar-Kyoto (WKY) rats of the same age were compared in vitro Intraluminal pressure (IPJ-diameter plots for resting, methoxamine (1 6x10"s mol/1) contracted and papaverine (2 8xl04 mol/1) relaxed segments were recorded Saphenous arteries of SHRSTZ showed larger contractile response, than those of SHR and WKY (act strain, at 100 mmHg IP: 10.03±2.70 vs. 7.12±4.1 vs. 0.35±0.46 %). Due to the enhanced smooth muscle tone distensibility and elastic modulus curves of SHR were shifted toward elastic direction but at in vivo pressure levels there was no difference in these parameters Diabetes caused arterial wall stiffening (distensibility, at 100 mmHg: 2.210.4 vs. 3.4+0.4x10-6 cm2/dyne). Although wall thickness and external radius of the SHR-STZ rats were decreased, lumen capacity of the three groups was not different. Saphenous vein of the SHR showed larger lumen capacity than veins of SHR-STZ and WKY (lumen capacity, at 8 mmHg IP 0.43 ±0.04 vs. 0.29 ±0.04 vs. 0.27±0 02 mm3/mm), but elastic and contractile parameters did not exhibit significant differences. We conclude that arterial responsiveness and venous capacity function are enhanced in hypertension, while diabetes causes arterial wall stiffening and decreased venous capacity in rats. Supported by grants ETT No. 291 93/94, OTKA No. T017789, and BIOREX Res & Dev Co.

UR - http://www.scopus.com/inward/record.url?scp=33749173334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749173334&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33749173334

VL - 10

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -