Various ulcerogenic stimuli are potentiated by glucocorticoid deficiency in rats

Ludmila Filaretova, Tatiana Bagaeva, Tatiana Podvigina, Gabor Makara

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effects of glucocorticoid deficiency with or without corticosterone replacement on susceptibility to gastric mucosal injury by various ulcerogenic stimuli have been evaluated in rats. Gastric erosions were induced in male rats by stimuli of different modalities and intensities: 20% ethanol (po), aspirin (300 mg/kg, ip), acidified aspirin (40 mM, po) and 100% acetic acid (applied to gastric serosa). Glucocorticoid supply was decreased by adrenalectomy or by delayed inhibitory action after a single pharmacological dose of cortisol (300 mg/kg, ip) injected one week before the onset of ulcerogenic stimulus. Corticosterone for replacement (4 mg/kg, sc) was injected in rats with glucocorticoid deficiency 15 min before the onset of ulcerogenic stimulus. Plasma corticosterone levels were measured by fluorometry. Gastric erosions were quantitated by measuring the area of damage. Ulcerogenic stimuli induced both plasma corticosterone rise and gastric mucosal injury. The area of mucosal damages induced various stimuli ranged from small to extensive. Glucocorticoid deficiency significantly potentiated an ulcerogenic action of every ulcerogenic stimulus. Replacing corticosterone prevented or significantly decreased erosion-potentiating effect of glucocorticoid deficiency. These results show that endogenous glucocorticoids released during ulcerogenic influences help gastric mucosa to resist a harmful action of both weak and strong ulcerogenic stimuli.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - Nov 12 2001

Keywords

  • Acetic acid
  • Aspirin
  • Ethanol
  • Gastric erosions
  • Glucocorticoid deficiency

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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