Various signal molecules modulate voltage-activated ion currents on snail neurons.

A. Szücs, G. B. Stefano, T. K. Hughes, K. S. Rózsa

Research output: Contribution to journalArticle

Abstract

The modulatory effects of interleukin-1 (IL-1), an immunotransmitter, and FMRFamide, a molluscan neuropeptide, were studied on identified neurons of Helix pomatia L. (Mollusca, Gastropoda) by using the method of two microelectrode voltage clamp. IL-1 and FMRFamide uniformly decreased the voltage-activated inward current (ICa), while the voltage-dependent outward potassium current (Inet K) increased. IL-1 and FMRFamide were shown to use the same cellular targets as used by the low molecular weight neurotransmitters.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalActa biochimica et biophysica Hungarica
Volume26
Issue number1-4
Publication statusPublished - Jan 1 1991

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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