Various proteinase inhibitors decrease prolactin and growth hormone release by anterior pituitary cells

György Rappay, Gábor B. Makara, Sándor Bajusz, Iván Nagy

Research output: Contribution to journalArticle

10 Citations (Scopus)


Proteinase inhibitors were tested for their ability to inhibit prolactin (PRL) and growth hormone (GH) release by cultured anterior pituitary cells of the rat. Inhibitors of microbial origin (chymostatin, elastatinal, leupeptin) had either no or a moderate effect on hormones release while some tripeptide aldehydes, especially those with lysine at their C terminus, inhibited markedly PRL and to a lesser extent GH release. Boc-DPhe-Phe-lysinal was the most effective on lactotrophs inhibiting PRL release more than 50% at 10-4 M. The site(s) of action of tripeptide aldehydes remain to be elucidated.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalLife Sciences
Issue number6
Publication statusPublished - Feb 11 1985


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this