Az idült májbetegségek progressziójához vezeto folyamatok

Translated title of the contribution: Various pathways leading to the progression of chronic liver diseases

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

As the result of various effects (viruses, metabolic diseases, nutritional factors, toxic agents, autoimmune processes) abnormal liver function, liver steatosis and connective tissue remodeling may develop. Progression of this process is complex including various pathways and a number of factors. The authors summarize the factors involved in the progression of chronic liver disease. They describe the role of cells and the produced inflammatory mediators and cytokines, as well as the relationship between the disease and the intestinal flora. They emphasize the role of oxidative stress, mitochondrial dysfunction and cell death in disease progression. Insulin resistance and micro-elements (iron, copper) in relation to liver damage are also discussed, and genetic and epigenetic aspects underlying disease progression are summarized. Discovery of novel treatment options, assessment of the effectiveness of treatment, as well as the success and proper timing of liver transplantation may depend on a better understanding of the process of disease progression.

Translated title of the contributionVarious pathways leading to the progression of chronic liver diseases
Original languageHungarian
Number of pages1
JournalOrvosi hetilap
Volume157
Issue number8
DOIs
Publication statusPublished - Feb 2016

ASJC Scopus subject areas

  • Medicine(all)

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