Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions

G. Cserni, Simonetta Bianchi, Vania Vezzosi, Paul van Diest, Carolien van Deurzen, István Sejben, Peter Regitnig, Martin Asslaber, Maria P. Foschini, Anna Sapino, Isabella Castellano, Grace Callagy, Evdokia Arkoumani, J. Kulka, Clive A. Wells

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Breast cancers with nodal isolated tumour cells (ITC) and micrometastases are categorised as node-negative and node-positive, respectively, in the tumour node metastasis (TNM) classification. Two recently published interpretations of the TNM definitions were applied to cases of low-volume sentinel lymph node (SLN) involvement and their corresponding non-SLNs for reclassification as micrometastasis or ITC. Of the 517 cases reviewed, 82 had ITC and 435 had micrometastasis on the basis of one classification, and the number of ITC increased to 207 with 310 micrometastases on the basis of the other. Approximately 24% of the cases were discordantly categorised. The rates of non-SLN metastases associated with SLN ITCs were 8.5% and 13.5%, respectively. Although the second interpretation of low-volume nodal stage categories has better reproducibility, it may underestimate the rate of non-SLN involvement. The TNM definitions of low-volume nodal metastases need to be better formulated and supplemented with visual information in the form of multiple sample images.

Original languageEnglish
Pages (from-to)2185-2191
Number of pages7
JournalEuropean Journal of Cancer
Volume44
Issue number15
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Neoplasm Micrometastasis
Neoplasm Metastasis
Neoplasms
Lymph Nodes
cyhalothrin
Breast Neoplasms

Keywords

  • Breast cancer
  • Isolated tumour cells
  • Micrometastasis
  • Sentinel lymph node
  • TNM

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions. / Cserni, G.; Bianchi, Simonetta; Vezzosi, Vania; van Diest, Paul; van Deurzen, Carolien; Sejben, István; Regitnig, Peter; Asslaber, Martin; Foschini, Maria P.; Sapino, Anna; Castellano, Isabella; Callagy, Grace; Arkoumani, Evdokia; Kulka, J.; Wells, Clive A.

In: European Journal of Cancer, Vol. 44, No. 15, 10.2008, p. 2185-2191.

Research output: Contribution to journalArticle

Cserni, G, Bianchi, S, Vezzosi, V, van Diest, P, van Deurzen, C, Sejben, I, Regitnig, P, Asslaber, M, Foschini, MP, Sapino, A, Castellano, I, Callagy, G, Arkoumani, E, Kulka, J & Wells, CA 2008, 'Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions', European Journal of Cancer, vol. 44, no. 15, pp. 2185-2191. https://doi.org/10.1016/j.ejca.2008.06.033
Cserni, G. ; Bianchi, Simonetta ; Vezzosi, Vania ; van Diest, Paul ; van Deurzen, Carolien ; Sejben, István ; Regitnig, Peter ; Asslaber, Martin ; Foschini, Maria P. ; Sapino, Anna ; Castellano, Isabella ; Callagy, Grace ; Arkoumani, Evdokia ; Kulka, J. ; Wells, Clive A. / Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions. In: European Journal of Cancer. 2008 ; Vol. 44, No. 15. pp. 2185-2191.
@article{131d4d5b57fa42d485addf956b4e7c48,
title = "Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions",
abstract = "Breast cancers with nodal isolated tumour cells (ITC) and micrometastases are categorised as node-negative and node-positive, respectively, in the tumour node metastasis (TNM) classification. Two recently published interpretations of the TNM definitions were applied to cases of low-volume sentinel lymph node (SLN) involvement and their corresponding non-SLNs for reclassification as micrometastasis or ITC. Of the 517 cases reviewed, 82 had ITC and 435 had micrometastasis on the basis of one classification, and the number of ITC increased to 207 with 310 micrometastases on the basis of the other. Approximately 24{\%} of the cases were discordantly categorised. The rates of non-SLN metastases associated with SLN ITCs were 8.5{\%} and 13.5{\%}, respectively. Although the second interpretation of low-volume nodal stage categories has better reproducibility, it may underestimate the rate of non-SLN involvement. The TNM definitions of low-volume nodal metastases need to be better formulated and supplemented with visual information in the form of multiple sample images.",
keywords = "Breast cancer, Isolated tumour cells, Micrometastasis, Sentinel lymph node, TNM",
author = "G. Cserni and Simonetta Bianchi and Vania Vezzosi and {van Diest}, Paul and {van Deurzen}, Carolien and Istv{\'a}n Sejben and Peter Regitnig and Martin Asslaber and Foschini, {Maria P.} and Anna Sapino and Isabella Castellano and Grace Callagy and Evdokia Arkoumani and J. Kulka and Wells, {Clive A.}",
year = "2008",
month = "10",
doi = "10.1016/j.ejca.2008.06.033",
language = "English",
volume = "44",
pages = "2185--2191",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "15",

}

TY - JOUR

T1 - Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions

AU - Cserni, G.

AU - Bianchi, Simonetta

AU - Vezzosi, Vania

AU - van Diest, Paul

AU - van Deurzen, Carolien

AU - Sejben, István

AU - Regitnig, Peter

AU - Asslaber, Martin

AU - Foschini, Maria P.

AU - Sapino, Anna

AU - Castellano, Isabella

AU - Callagy, Grace

AU - Arkoumani, Evdokia

AU - Kulka, J.

AU - Wells, Clive A.

PY - 2008/10

Y1 - 2008/10

N2 - Breast cancers with nodal isolated tumour cells (ITC) and micrometastases are categorised as node-negative and node-positive, respectively, in the tumour node metastasis (TNM) classification. Two recently published interpretations of the TNM definitions were applied to cases of low-volume sentinel lymph node (SLN) involvement and their corresponding non-SLNs for reclassification as micrometastasis or ITC. Of the 517 cases reviewed, 82 had ITC and 435 had micrometastasis on the basis of one classification, and the number of ITC increased to 207 with 310 micrometastases on the basis of the other. Approximately 24% of the cases were discordantly categorised. The rates of non-SLN metastases associated with SLN ITCs were 8.5% and 13.5%, respectively. Although the second interpretation of low-volume nodal stage categories has better reproducibility, it may underestimate the rate of non-SLN involvement. The TNM definitions of low-volume nodal metastases need to be better formulated and supplemented with visual information in the form of multiple sample images.

AB - Breast cancers with nodal isolated tumour cells (ITC) and micrometastases are categorised as node-negative and node-positive, respectively, in the tumour node metastasis (TNM) classification. Two recently published interpretations of the TNM definitions were applied to cases of low-volume sentinel lymph node (SLN) involvement and their corresponding non-SLNs for reclassification as micrometastasis or ITC. Of the 517 cases reviewed, 82 had ITC and 435 had micrometastasis on the basis of one classification, and the number of ITC increased to 207 with 310 micrometastases on the basis of the other. Approximately 24% of the cases were discordantly categorised. The rates of non-SLN metastases associated with SLN ITCs were 8.5% and 13.5%, respectively. Although the second interpretation of low-volume nodal stage categories has better reproducibility, it may underestimate the rate of non-SLN involvement. The TNM definitions of low-volume nodal metastases need to be better formulated and supplemented with visual information in the form of multiple sample images.

KW - Breast cancer

KW - Isolated tumour cells

KW - Micrometastasis

KW - Sentinel lymph node

KW - TNM

UR - http://www.scopus.com/inward/record.url?scp=84877330935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877330935&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2008.06.033

DO - 10.1016/j.ejca.2008.06.033

M3 - Article

VL - 44

SP - 2185

EP - 2191

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 15

ER -