Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Amy L. Sherborne, Fay J. Hosking, Rashmi B. Prasad, Rajiv Kumar, Rolf Koehler, Jayaram Vijayakrishnan, Elli Papaemmanuil, Claus R. Bartram, Martin Stanulla, Martin Schrappe, Andreas Gast, Sara E. Dobbins, Yussanne Ma, Eamonn Sheridan, Malcolm Taylor, Sally E. Kinsey, Tracey Lightfoot, Eve Roman, Julie A E Irving, James M. Allan & 18 others Anthony V. Moorman, Christine J. Harrison, Ian P. Tomlinson, Sue Richards, Martin Zimmermann, C. Szalai, Ågnes F. Semsei, Daniel J. Erdelyi, Maja Krajinovic, Daniel Sinnett, Jasmine Healy, Anna Gonzalez Neira, Norihiko Kawamata, Seishi Ogawa, H. Phillip Koeffler, Kari Hemminki, Mel Greaves, Richard S. Houlston

Research output: Contribution to journalArticle

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Abstract

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10 -11), irrespective of cell lineage.

Original languageEnglish
Pages (from-to)492-494
Number of pages3
JournalNature Genetics
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 2010

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Odds Ratio
Genome-Wide Association Study
Cell Lineage
Introns

ASJC Scopus subject areas

  • Genetics

Cite this

Sherborne, A. L., Hosking, F. J., Prasad, R. B., Kumar, R., Koehler, R., Vijayakrishnan, J., ... Houlston, R. S. (2010). Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nature Genetics, 42(6), 492-494. https://doi.org/10.1038/ng.585

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. / Sherborne, Amy L.; Hosking, Fay J.; Prasad, Rashmi B.; Kumar, Rajiv; Koehler, Rolf; Vijayakrishnan, Jayaram; Papaemmanuil, Elli; Bartram, Claus R.; Stanulla, Martin; Schrappe, Martin; Gast, Andreas; Dobbins, Sara E.; Ma, Yussanne; Sheridan, Eamonn; Taylor, Malcolm; Kinsey, Sally E.; Lightfoot, Tracey; Roman, Eve; Irving, Julie A E; Allan, James M.; Moorman, Anthony V.; Harrison, Christine J.; Tomlinson, Ian P.; Richards, Sue; Zimmermann, Martin; Szalai, C.; Semsei, Ågnes F.; Erdelyi, Daniel J.; Krajinovic, Maja; Sinnett, Daniel; Healy, Jasmine; Neira, Anna Gonzalez; Kawamata, Norihiko; Ogawa, Seishi; Koeffler, H. Phillip; Hemminki, Kari; Greaves, Mel; Houlston, Richard S.

In: Nature Genetics, Vol. 42, No. 6, 06.2010, p. 492-494.

Research output: Contribution to journalArticle

Sherborne, AL, Hosking, FJ, Prasad, RB, Kumar, R, Koehler, R, Vijayakrishnan, J, Papaemmanuil, E, Bartram, CR, Stanulla, M, Schrappe, M, Gast, A, Dobbins, SE, Ma, Y, Sheridan, E, Taylor, M, Kinsey, SE, Lightfoot, T, Roman, E, Irving, JAE, Allan, JM, Moorman, AV, Harrison, CJ, Tomlinson, IP, Richards, S, Zimmermann, M, Szalai, C, Semsei, ÅF, Erdelyi, DJ, Krajinovic, M, Sinnett, D, Healy, J, Neira, AG, Kawamata, N, Ogawa, S, Koeffler, HP, Hemminki, K, Greaves, M & Houlston, RS 2010, 'Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk', Nature Genetics, vol. 42, no. 6, pp. 492-494. https://doi.org/10.1038/ng.585
Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J et al. Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nature Genetics. 2010 Jun;42(6):492-494. https://doi.org/10.1038/ng.585
Sherborne, Amy L. ; Hosking, Fay J. ; Prasad, Rashmi B. ; Kumar, Rajiv ; Koehler, Rolf ; Vijayakrishnan, Jayaram ; Papaemmanuil, Elli ; Bartram, Claus R. ; Stanulla, Martin ; Schrappe, Martin ; Gast, Andreas ; Dobbins, Sara E. ; Ma, Yussanne ; Sheridan, Eamonn ; Taylor, Malcolm ; Kinsey, Sally E. ; Lightfoot, Tracey ; Roman, Eve ; Irving, Julie A E ; Allan, James M. ; Moorman, Anthony V. ; Harrison, Christine J. ; Tomlinson, Ian P. ; Richards, Sue ; Zimmermann, Martin ; Szalai, C. ; Semsei, Ågnes F. ; Erdelyi, Daniel J. ; Krajinovic, Maja ; Sinnett, Daniel ; Healy, Jasmine ; Neira, Anna Gonzalez ; Kawamata, Norihiko ; Ogawa, Seishi ; Koeffler, H. Phillip ; Hemminki, Kari ; Greaves, Mel ; Houlston, Richard S. / Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. In: Nature Genetics. 2010 ; Vol. 42, No. 6. pp. 492-494.
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