Variable Biologie der Lungentumoren

Translated title of the contribution: Variation in biology of lung tumors: Prognostic factors by the pathologist?

K. M. Muller, T. Wiethege, E. Tolnay, K. Junker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Lung tumors are worldwide the leading cause of cancer death in men and women. Therapy, prognosis, and course of disease depend on size, localisation, and leading histological type of the tumor - more than 50% are heterogenious - at the time of diagnosis. Low performance status. N1 in TNM classification point to generalization of the disease. Genetic anomalies as activation of oncogenes, inactivation of tumor suppressor genes, disturbances of intracellular contact, various immunological reactions in different tumor regions, and a complex process of metastasis, will determine the further course. In spite of numerous parameters not one single marker is suitable for screening nor is it reliable for prognosis. In a selective utilization of different parameters however, it seems to be possible, by evaluating groups with a similar course, to give recommendations for therapy.

Translated title of the contributionVariation in biology of lung tumors: Prognostic factors by the pathologist?
Original languageGerman
Pages (from-to)302-307
Number of pages6
JournalAtemwegs- und Lungenkrankheiten
Volume23
Issue number6
Publication statusPublished - Jan 1 1997

Keywords

  • Lung tumors
  • Pathology
  • Performance status
  • Prognosis
  • TNM classification
  • Tumor marker
  • erbB-2-gene
  • p53 tumor suppressor gene

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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  • Cite this

    Muller, K. M., Wiethege, T., Tolnay, E., & Junker, K. (1997). Variable Biologie der Lungentumoren. Atemwegs- und Lungenkrankheiten, 23(6), 302-307.