Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease

Eva C. Schulte, Brit Mollenhauer, Alexander Zimprich, Benjamin Bereznai, Peter Lichtner, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Maria J. Molnar, Annette Peters, Christian Gieger, Claudia Trenkwalder, Juliane Winkelmann

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22 Citations (Scopus)

Abstract

Recently, mutations in eukaryotic translation initiation factor 4G1 (EIF4G1) were reported as a rare cause of familial Parkinson's disease (PD). We screened the 33 exons of EIF4G1 by high-resolution melting curve analysis for variants in our Central European cohort of 376 PD cases. Variant frequency was assessed in a total of 975 PD cases and 1,014 general population controls. Eight novel nonsynonymous and four synonymous variants were identified. In our cohort, novel and previously identified nonsynonymous variants were very rare. Although it is possible that our general population controls also comprise individuals who have or could develop PD in the future, the presence of the original mutation (EIF4G1 p.Arg1205 His) in three controls only, raises questions about the causality of this variant with regard to PD.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalNeurogenetics
Volume13
Issue number3
DOIs
Publication statusPublished - Aug 1 2012

Keywords

  • EIF4G1
  • Genetics
  • Parkinson's disease
  • Rare variants

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Cellular and Molecular Neuroscience

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    Schulte, E. C., Mollenhauer, B., Zimprich, A., Bereznai, B., Lichtner, P., Haubenberger, D., Pirker, W., Brücke, T., Molnar, M. J., Peters, A., Gieger, C., Trenkwalder, C., & Winkelmann, J. (2012). Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease. Neurogenetics, 13(3), 281-285. https://doi.org/10.1007/s10048-012-0334-9