Variance of ACE and AT1 receptor gene does not influence the risk of neonatal acute renal failure

A. Nobilis, I. Kocsis, P. Tóth-Heyn, A. Treszl, A. Schuler, T. Tulassay, B. Vásárhelyi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

High neonatal activity of the renin-angiotensin system (RAS) is crucial for the maintenance of glomerular filtration of the newborn. The aim of the present study was to investigate whether genetic polymorphisms leading to lower angiotensin converting enzyme activity (ACE) or impaired functionality of angiotensin II (AII) type 1 receptor (AT1R) might predispose very low birth weight newborns (VLBWs) to the development of acute renal failure (ARF). The medical records of 110 VLBW infants were analyzed. ARF developed in 42 of them during the first postnatal week, while 68 neonates exhibited normal renal function. The ACE I/D polymorphism and the A1166C variants of AT1R were determined from dried blood samples. The frequency of the ACE I allele did not differ in ARF and non-ARF groups (0.307 and 0.284); the frequency of the AT1R C1166 variant was also the same in ARF and non-ARF groups (0.250 and 0.227). Although low activity of RAS has been implicated in the development of neonatal ARF and data indicated that the functionality of RAS is influenced by the I/D variants of the ACE gene and the A1166C variant of the AT1R gene, we could not demonstrate any effect of these polymorphisms on the development of ARF in VLBW infants.

Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalPediatric Nephrology
Volume16
Issue number12
DOIs
Publication statusPublished - 2001

Fingerprint

Peptidyl-Dipeptidase A
Acute Kidney Injury
Very Low Birth Weight Infant
Newborn Infant
Renin-Angiotensin System
Genes
Renal Insufficiency
Angiotensin Type 1 Receptor
Genetic Polymorphisms
Medical Records
Alleles
Maintenance
Kidney

Keywords

  • Acute renal failure
  • Angiotensin converting enzyme
  • Angiotensin II type 1 receptor
  • Genetic polymorphism
  • Very low birth weight infant

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Variance of ACE and AT1 receptor gene does not influence the risk of neonatal acute renal failure. / Nobilis, A.; Kocsis, I.; Tóth-Heyn, P.; Treszl, A.; Schuler, A.; Tulassay, T.; Vásárhelyi, B.

In: Pediatric Nephrology, Vol. 16, No. 12, 2001, p. 1063-1066.

Research output: Contribution to journalArticle

Nobilis, A. ; Kocsis, I. ; Tóth-Heyn, P. ; Treszl, A. ; Schuler, A. ; Tulassay, T. ; Vásárhelyi, B. / Variance of ACE and AT1 receptor gene does not influence the risk of neonatal acute renal failure. In: Pediatric Nephrology. 2001 ; Vol. 16, No. 12. pp. 1063-1066.
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