Variability of the PreS1/PreS2/S regions of hepatitis B virus in Hungary

K. N. Szomor, Á Dencs, G. Tóth, G. Kovács, Y. Saleh Ali, G. Berencsi, M. Takács

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Infection with the hepatitis B virus can occur perinatally, parenterally, or sexually, and it can cause acute or chronic liver diseases. Phylogenetic analysis of the virus has led to its classification into eight genotypes (A-H), which show a characteristic worldwide distribution. The aim of this study was to reveal the HBV genotypes present in Hungary and to investigate a nosocomial and an intrafamilial outbreak. The collected samples were tested by nested PCR, and a 650-nucleotide-long segment of the preS1/preS2/S region was sequenced. As no previous genotype data were available from Hungary, sera of 24 HBsAg-positive patients were collected from different regions of the country. They also served as control samples for the molecular epidemiologic study. Nineteen of them carried genotype D of hepatitis B virus, and five of them carried genotype A. Twenty-nine patients from a haemato-oncology unit were affected in a nosocomial outbreak. The patients had haematological and/or oncological diseases, most of them were immunosuppressed. In twenty-eight cases, based on phylogenetic analysis of the viruses, there was presumably a common source of infection, and an epidemiological investigation showed that the infections seemed to be hospital-acquired. In the intrafamilial outbreak, two asymptomatic carrier children infected their foster mother. The three sequences were totally identical.

Original languageEnglish
Pages (from-to)697-704
Number of pages8
JournalArchives of Virology
Volume152
Issue number4
DOIs
Publication statusPublished - Apr 2007

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Hungary
Hepatitis B virus
Genotype
Disease Outbreaks
Infection
Viruses
Hepatitis B Surface Antigens
Liver Diseases
Epidemiologic Studies
Chronic Disease
Nucleotides
Mothers
Polymerase Chain Reaction
Serum

ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

Cite this

Variability of the PreS1/PreS2/S regions of hepatitis B virus in Hungary. / Szomor, K. N.; Dencs, Á; Tóth, G.; Kovács, G.; Saleh Ali, Y.; Berencsi, G.; Takács, M.

In: Archives of Virology, Vol. 152, No. 4, 04.2007, p. 697-704.

Research output: Contribution to journalArticle

Szomor, K. N. ; Dencs, Á ; Tóth, G. ; Kovács, G. ; Saleh Ali, Y. ; Berencsi, G. ; Takács, M. / Variability of the PreS1/PreS2/S regions of hepatitis B virus in Hungary. In: Archives of Virology. 2007 ; Vol. 152, No. 4. pp. 697-704.
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