Vanadium(III) binding strengths of small biomolecules

P. Buglyó, Eszter Márta Nagy, I. Sóvágó

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The hydrolysis of vanadium(III) and the complex formation reactions between V(III) and weakly coordinating [glycine (GLY), DL-aspartic acid (ASP), D-penicillamine (PEN), DL-histidine (HIS)] or strongly coordinating [N,O] donor [picolinic (PIC) or 6-methylpicolinic acid (MePIC)] and [O,O] donor [maltol (MALT), 1,2-dimethyl-3-hydroxy-4-(1H)-pyridinone (DHP), tiron (TIR)] ligands were studied at 25.0 °C and an ionic strength of 0.20 M (KCl) in aqueous solution using combined pH-potentiometric and UV-vis spectroscopic techniques. Although some interaction between the amino acids and V(III) was found, we could not obtain reliable models for these systems owing to the intensive hydrolysis of the metal ion and the formation of polynuclear hydroxo complexes. With pyridine carboxylates or [O,O] donor ligands 1:1, 1:2 (in the latter case, also 1:3 species) were found to be present as major complexes in solution. The similarities and differences in binding V(III) by these ligands are discussed.

Original languageEnglish
Pages (from-to)1583-1594
Number of pages12
JournalPure and Applied Chemistry
Volume77
Issue number9
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Vanadium
Biomolecules
Ligands
Amino acids
Hydrolysis
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
Penicillamine
Acids
Ionic strength
Histidine
Aspartic Acid
Pyridine
Glycine
Metal ions
Amino Acids

Keywords

  • Complex equilibria
  • Deferriprone
  • Insulin mimetic complex
  • Maltol
  • Picolinate
  • Speciation
  • Vanadium(III)

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Vanadium(III) binding strengths of small biomolecules. / Buglyó, P.; Nagy, Eszter Márta; Sóvágó, I.

In: Pure and Applied Chemistry, Vol. 77, No. 9, 09.2005, p. 1583-1594.

Research output: Contribution to journalArticle

@article{b02041afe9004c34a0d52656066d375f,
title = "Vanadium(III) binding strengths of small biomolecules",
abstract = "The hydrolysis of vanadium(III) and the complex formation reactions between V(III) and weakly coordinating [glycine (GLY), DL-aspartic acid (ASP), D-penicillamine (PEN), DL-histidine (HIS)] or strongly coordinating [N,O] donor [picolinic (PIC) or 6-methylpicolinic acid (MePIC)] and [O,O] donor [maltol (MALT), 1,2-dimethyl-3-hydroxy-4-(1H)-pyridinone (DHP), tiron (TIR)] ligands were studied at 25.0 °C and an ionic strength of 0.20 M (KCl) in aqueous solution using combined pH-potentiometric and UV-vis spectroscopic techniques. Although some interaction between the amino acids and V(III) was found, we could not obtain reliable models for these systems owing to the intensive hydrolysis of the metal ion and the formation of polynuclear hydroxo complexes. With pyridine carboxylates or [O,O] donor ligands 1:1, 1:2 (in the latter case, also 1:3 species) were found to be present as major complexes in solution. The similarities and differences in binding V(III) by these ligands are discussed.",
keywords = "Complex equilibria, Deferriprone, Insulin mimetic complex, Maltol, Picolinate, Speciation, Vanadium(III)",
author = "P. Bugly{\'o} and Nagy, {Eszter M{\'a}rta} and I. S{\'o}v{\'a}g{\'o}",
year = "2005",
month = "9",
doi = "10.1351/pac200577091583",
language = "English",
volume = "77",
pages = "1583--1594",
journal = "Pure and Applied Chemistry",
issn = "0033-4545",
publisher = "IUPAC Secretariat",
number = "9",

}

TY - JOUR

T1 - Vanadium(III) binding strengths of small biomolecules

AU - Buglyó, P.

AU - Nagy, Eszter Márta

AU - Sóvágó, I.

PY - 2005/9

Y1 - 2005/9

N2 - The hydrolysis of vanadium(III) and the complex formation reactions between V(III) and weakly coordinating [glycine (GLY), DL-aspartic acid (ASP), D-penicillamine (PEN), DL-histidine (HIS)] or strongly coordinating [N,O] donor [picolinic (PIC) or 6-methylpicolinic acid (MePIC)] and [O,O] donor [maltol (MALT), 1,2-dimethyl-3-hydroxy-4-(1H)-pyridinone (DHP), tiron (TIR)] ligands were studied at 25.0 °C and an ionic strength of 0.20 M (KCl) in aqueous solution using combined pH-potentiometric and UV-vis spectroscopic techniques. Although some interaction between the amino acids and V(III) was found, we could not obtain reliable models for these systems owing to the intensive hydrolysis of the metal ion and the formation of polynuclear hydroxo complexes. With pyridine carboxylates or [O,O] donor ligands 1:1, 1:2 (in the latter case, also 1:3 species) were found to be present as major complexes in solution. The similarities and differences in binding V(III) by these ligands are discussed.

AB - The hydrolysis of vanadium(III) and the complex formation reactions between V(III) and weakly coordinating [glycine (GLY), DL-aspartic acid (ASP), D-penicillamine (PEN), DL-histidine (HIS)] or strongly coordinating [N,O] donor [picolinic (PIC) or 6-methylpicolinic acid (MePIC)] and [O,O] donor [maltol (MALT), 1,2-dimethyl-3-hydroxy-4-(1H)-pyridinone (DHP), tiron (TIR)] ligands were studied at 25.0 °C and an ionic strength of 0.20 M (KCl) in aqueous solution using combined pH-potentiometric and UV-vis spectroscopic techniques. Although some interaction between the amino acids and V(III) was found, we could not obtain reliable models for these systems owing to the intensive hydrolysis of the metal ion and the formation of polynuclear hydroxo complexes. With pyridine carboxylates or [O,O] donor ligands 1:1, 1:2 (in the latter case, also 1:3 species) were found to be present as major complexes in solution. The similarities and differences in binding V(III) by these ligands are discussed.

KW - Complex equilibria

KW - Deferriprone

KW - Insulin mimetic complex

KW - Maltol

KW - Picolinate

KW - Speciation

KW - Vanadium(III)

UR - http://www.scopus.com/inward/record.url?scp=26644461670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26644461670&partnerID=8YFLogxK

U2 - 10.1351/pac200577091583

DO - 10.1351/pac200577091583

M3 - Article

AN - SCOPUS:26644461670

VL - 77

SP - 1583

EP - 1594

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

SN - 0033-4545

IS - 9

ER -