Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty

M. Albertal, E. Regar, J. J. Piek, G. Van Langenhove, S. G. Carlier, A. Thury, G. Sianos, E. Boersma, B. De Bruyne, C. Di Mario, P. W. Serruys

Research output: Contribution to journalArticle

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Abstract

Background: The coronary flow velocity acceleration at the stenotic site (SVA), defined as a ≥50% increase in resting stenotic velocity when compared with the reference segment, has been shown to be highly sensitive and specific for the diagnosis of a hemodynamically significant stenosis. In this study, we describe the value of postprocedural SVA for the prediction of a lack of improvement in functional activity at long-term follow-up balloon angioplasty (BA). Methods: We investigated the improvement in functional activity in patients undergoing single native vessel angioplasty and intracoronary Doppler (before BA, after BA, and again at 6-month follow-up) as part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) I trial. Lack of improvement was defined as no change in Duke Activity Status Index (DASI) at 6-month follow-up, whereas SVA was defined as ≥50% elevation in resting velocity at the treated area compared with the distal measurement. Results: SVA was found more frequently in patients without improvement in DASI (45% vs 31%, P = .03). Similar percent diameter stenosis and coronary flow velocity reserve were observed in patients with and those without improvement in DASI at follow-up. By multivariate regression analysis, the presence of SVA (P = .029; odds ratio, 1.97; 95% confidence interval, 1.07 to 3.63) and an elevated DASI at baseline (P <.001; odds ratio, 1.05; 95% confidence interval, 1.03 to 1.07) were associated with a lack of improvement at follow-up. Conclusions: The detection of SVA was associated with failure of improvement in functional activity at follow-up after coronary intervention.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalAmerican Heart Journal
Volume142
Issue number1
DOIs
Publication statusPublished - 2001

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Balloon Angioplasty
Angioplasty
Odds Ratio
Confidence Intervals
Coronary Stenosis
Pathologic Constriction
Multivariate Analysis
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty. / Albertal, M.; Regar, E.; Piek, J. J.; Langenhove, G. Van; Carlier, S. G.; Thury, A.; Sianos, G.; Boersma, E.; De Bruyne, B.; Di Mario, C.; Serruys, P. W.

In: American Heart Journal, Vol. 142, No. 1, 2001, p. 81-86.

Research output: Contribution to journalArticle

Albertal, M, Regar, E, Piek, JJ, Langenhove, GV, Carlier, SG, Thury, A, Sianos, G, Boersma, E, De Bruyne, B, Di Mario, C & Serruys, PW 2001, 'Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty', American Heart Journal, vol. 142, no. 1, pp. 81-86. https://doi.org/10.1067/mhj.2001.115590
Albertal, M. ; Regar, E. ; Piek, J. J. ; Langenhove, G. Van ; Carlier, S. G. ; Thury, A. ; Sianos, G. ; Boersma, E. ; De Bruyne, B. ; Di Mario, C. ; Serruys, P. W. / Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty. In: American Heart Journal. 2001 ; Vol. 142, No. 1. pp. 81-86.
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abstract = "Background: The coronary flow velocity acceleration at the stenotic site (SVA), defined as a ≥50{\%} increase in resting stenotic velocity when compared with the reference segment, has been shown to be highly sensitive and specific for the diagnosis of a hemodynamically significant stenosis. In this study, we describe the value of postprocedural SVA for the prediction of a lack of improvement in functional activity at long-term follow-up balloon angioplasty (BA). Methods: We investigated the improvement in functional activity in patients undergoing single native vessel angioplasty and intracoronary Doppler (before BA, after BA, and again at 6-month follow-up) as part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) I trial. Lack of improvement was defined as no change in Duke Activity Status Index (DASI) at 6-month follow-up, whereas SVA was defined as ≥50{\%} elevation in resting velocity at the treated area compared with the distal measurement. Results: SVA was found more frequently in patients without improvement in DASI (45{\%} vs 31{\%}, P = .03). Similar percent diameter stenosis and coronary flow velocity reserve were observed in patients with and those without improvement in DASI at follow-up. By multivariate regression analysis, the presence of SVA (P = .029; odds ratio, 1.97; 95{\%} confidence interval, 1.07 to 3.63) and an elevated DASI at baseline (P <.001; odds ratio, 1.05; 95{\%} confidence interval, 1.03 to 1.07) were associated with a lack of improvement at follow-up. Conclusions: The detection of SVA was associated with failure of improvement in functional activity at follow-up after coronary intervention.",
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T1 - Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty

AU - Albertal, M.

AU - Regar, E.

AU - Piek, J. J.

AU - Langenhove, G. Van

AU - Carlier, S. G.

AU - Thury, A.

AU - Sianos, G.

AU - Boersma, E.

AU - De Bruyne, B.

AU - Di Mario, C.

AU - Serruys, P. W.

PY - 2001

Y1 - 2001

N2 - Background: The coronary flow velocity acceleration at the stenotic site (SVA), defined as a ≥50% increase in resting stenotic velocity when compared with the reference segment, has been shown to be highly sensitive and specific for the diagnosis of a hemodynamically significant stenosis. In this study, we describe the value of postprocedural SVA for the prediction of a lack of improvement in functional activity at long-term follow-up balloon angioplasty (BA). Methods: We investigated the improvement in functional activity in patients undergoing single native vessel angioplasty and intracoronary Doppler (before BA, after BA, and again at 6-month follow-up) as part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) I trial. Lack of improvement was defined as no change in Duke Activity Status Index (DASI) at 6-month follow-up, whereas SVA was defined as ≥50% elevation in resting velocity at the treated area compared with the distal measurement. Results: SVA was found more frequently in patients without improvement in DASI (45% vs 31%, P = .03). Similar percent diameter stenosis and coronary flow velocity reserve were observed in patients with and those without improvement in DASI at follow-up. By multivariate regression analysis, the presence of SVA (P = .029; odds ratio, 1.97; 95% confidence interval, 1.07 to 3.63) and an elevated DASI at baseline (P <.001; odds ratio, 1.05; 95% confidence interval, 1.03 to 1.07) were associated with a lack of improvement at follow-up. Conclusions: The detection of SVA was associated with failure of improvement in functional activity at follow-up after coronary intervention.

AB - Background: The coronary flow velocity acceleration at the stenotic site (SVA), defined as a ≥50% increase in resting stenotic velocity when compared with the reference segment, has been shown to be highly sensitive and specific for the diagnosis of a hemodynamically significant stenosis. In this study, we describe the value of postprocedural SVA for the prediction of a lack of improvement in functional activity at long-term follow-up balloon angioplasty (BA). Methods: We investigated the improvement in functional activity in patients undergoing single native vessel angioplasty and intracoronary Doppler (before BA, after BA, and again at 6-month follow-up) as part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) I trial. Lack of improvement was defined as no change in Duke Activity Status Index (DASI) at 6-month follow-up, whereas SVA was defined as ≥50% elevation in resting velocity at the treated area compared with the distal measurement. Results: SVA was found more frequently in patients without improvement in DASI (45% vs 31%, P = .03). Similar percent diameter stenosis and coronary flow velocity reserve were observed in patients with and those without improvement in DASI at follow-up. By multivariate regression analysis, the presence of SVA (P = .029; odds ratio, 1.97; 95% confidence interval, 1.07 to 3.63) and an elevated DASI at baseline (P <.001; odds ratio, 1.05; 95% confidence interval, 1.03 to 1.07) were associated with a lack of improvement at follow-up. Conclusions: The detection of SVA was associated with failure of improvement in functional activity at follow-up after coronary intervention.

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U2 - 10.1067/mhj.2001.115590

DO - 10.1067/mhj.2001.115590

M3 - Article

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EP - 86

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

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