Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology

M. Gulyás, A. Kaposi, G. Elek, L. G. Szollár, A. Hjerpe

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aim - To determine whether assays of carcinoembryonic antigen (CEA) and cholesterol in ascites add diagnostic value to cytology. Methods - The additional diagnostic efficacy of the biochemical assays was studied in the ascitic fluid from 130 patients, of whom 57 had peritoneal carcinomatosis. All diagnoses were verified by subsequent necropsy and/or histology. Results - CEA concentrations over 5 ng/ml indicated carcinomas, occasionally without peritoneal involvement of the tumour. However, increased values were significantly more common in cancer with peritoneal involvement (p <0.01), giving a sensitivity of 51% and specificity of 97% for carcinomatosis. A cholesterol value exceeding 1.21 mmol/litre was found in 93% of cancers with peritoneal involvement, but it was not entirely specific (96%) for carcinomatosis. Simultaneous increases in CEA and cholesterol concentrations were specific for carcinomatosis and this combination increased the sensitivity for diagnosing carcinomatosis from 77% with cytology alone to 88%. The correct diagnosis could thus be made in five of 12 cases with inconclusive cytology. Conclusions - The measurements of both CEA and cholesterol concentrations in ascites give additional specific information about peritoneal carcinomatosis and can therefore be a useful adjunct to cytology - in particular, in inconclusive cases.

Original languageEnglish
Pages (from-to)831-835
Number of pages5
JournalJournal of Clinical Pathology
Volume54
Issue number11
Publication statusPublished - 2001

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Ascitic Fluid
Carcinoembryonic Antigen
Cell Biology
Cholesterol
Carcinoma
Ascites
Neoplasms
Histology
Sensitivity and Specificity

Keywords

  • Ascitic fluid
  • Carcinoembryonic antigen
  • Cholesterol
  • Cytology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic fluid in cases of inconclusive cytology. / Gulyás, M.; Kaposi, A.; Elek, G.; Szollár, L. G.; Hjerpe, A.

In: Journal of Clinical Pathology, Vol. 54, No. 11, 2001, p. 831-835.

Research output: Contribution to journalArticle

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AU - Szollár, L. G.

AU - Hjerpe, A.

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