Value of axillary sentinel nodal status in breast cancer

G. Cserni, Gábor Boross, Béla Baltás

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Axillary clearance in node-negative breast cancer patients is performed only for staging and prognostic purposes. The sentinel node concept may provide an alternative conservative approach for these patients. This paper reports on the learning experience with lymphatic mapping involving the use of patent blue dye for the identification of sentinel lymph nodes (SLNs), followed by axillary dissection. The histopathology of the SLNs included serial sectioning and immunostaining for cytokeratin and epithelial membrane antigen, the remaining nodes being processed as usual. Of the 70 mapping procedures, 58 were successful; the surgical performance revealed a well defined learning period. The mean diameter of the successfully mapped tumors was 2.4 cm (ranging from in situ carcinoma to 4.8-cm invasive cancer). The mean numbers of SLNs and non-SLNs were 1.3 (range 1-3) and 19 (range 7-42), respectively. There were 36 SLN-positive cases, 21 of which had metastases only to these nodes. There were 19 node-negative cases, and 3 SLNs were falsely negative. Possible causes of the errors during lymphatic mapping are analyzed in the light of experiences published to date. SLN biopsy seems a good approach to enhancing the selectivity of axillary lymphadenectomy, but the limitations of the procedure must be evaluated and carefully considered.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalWorld Journal of Surgery
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 2000

Fingerprint

Breast Neoplasms
Learning
Sentinel Lymph Node Biopsy
Mucin-1
Carcinoma in Situ
Keratins
Lymph Node Excision
Dissection
Neoplasms
Coloring Agents
Lymph Nodes
Sentinel Lymph Node
cyhalothrin
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery

Cite this

Value of axillary sentinel nodal status in breast cancer. / Cserni, G.; Boross, Gábor; Baltás, Béla.

In: World Journal of Surgery, Vol. 24, No. 3, 03.2000, p. 341-344.

Research output: Contribution to journalArticle

Cserni, G. ; Boross, Gábor ; Baltás, Béla. / Value of axillary sentinel nodal status in breast cancer. In: World Journal of Surgery. 2000 ; Vol. 24, No. 3. pp. 341-344.
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