Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model

Sebastian Ley, Roland Unterhinninghofen, Julia Ley-Zaporozhan, Jens Peter Schenk, Hans Ulrich Kauczor, G. Szabó

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVES: Phase-contrast flow magnetic resonance imaging (pc-MRI) measurements are an established technique for noninvasive assessment of hemodynamics. However, in vivo validation data on the accuracy of pc-flow especially for nonphysiologic hemodynamic conditions are missing. The goal of our work was 1) to validate pc-flow with perivascular ultrasound in different hemodynamic conditions in the main pulmonary artery (MPA) and ascending aorta (AO) and 2) to investigate the relation between pc-MRI and invasive pressure measurements. MATERIALS AND METHODS: Five healthy pigs with opened chest were investigated. Ultrasound measurements were performed outside the MRI unit using a detachable MR-table. Parallel to ultrasound flow measurements, invasive pressure measurements were performed. PC-MRI (1.5 T MRI) measurements were done using a FLASH 2-dimensional sequence. First the animals were examined in normotonia, followed by hypertension (infusion of Arterenol) and hypotension (infusion of Sodiumnitropussid). RESULTS: Flow measurements acquired in normotonia were 2.7 ± 0.6 L/min (ultrasound) and 2.8 ± 0.6 L/min for pc-MRI (not significantly different, P = 0.17). During hypertonia, the blood flow increased to 3.1 ± 0.7 and 2.7 ± 0.8 L/min, respectively (P = 0.01). During hypotension, the blood flow decreased to 1.7 ± 0.5 and 1.7 ± 0.5 L/min, respectively (P = 0.7). An excellent linear correlation (taking all measurements together) between the ultrasound and pc-MRI measurements was found (r = 0.89). 95% Limits of intraindividual agreement correspond to relative differences of -36 to 44%. Systolic pressure measurements in the AO were 91 mm Hg (normotonic), 111 mm Hg (hypertonic), and 64 mm Hg (hypotonic) and in the MPA 23 mm Hg (normotonic), 29 mm Hg (hypertonic), and 20 mm Hg (hypotonic). Systolic pressure measurements showed good linear correlation with pc-MRI average flow per minute and peak velocity (AO: r = 0.79, MPA: r = 0.66). CONCLUSION: MRI pc-flow measurements are a reliable tool for noninvasive assessment of blood flow. Hemodynamic parameters derived by MRI demonstrate good linear correlations with the pressure in the systemic and pulmonary arterial circulation.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalInvestigative Radiology
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Pulmonary Artery
Aorta
Magnetic Resonance Spectroscopy
Animal Models
Magnetic Resonance Imaging
Hemodynamics
Pressure
Hypotension
Blood Pressure
Pulmonary Circulation
Norepinephrine
Swine
Thorax
Hypertension

Keywords

  • Animal
  • MRI
  • Perivascular ultrasound
  • Phase contrast flow
  • Validation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model. / Ley, Sebastian; Unterhinninghofen, Roland; Ley-Zaporozhan, Julia; Schenk, Jens Peter; Kauczor, Hans Ulrich; Szabó, G.

In: Investigative Radiology, Vol. 43, No. 6, 06.2008, p. 421-426.

Research output: Contribution to journalArticle

Ley, Sebastian ; Unterhinninghofen, Roland ; Ley-Zaporozhan, Julia ; Schenk, Jens Peter ; Kauczor, Hans Ulrich ; Szabó, G. / Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model. In: Investigative Radiology. 2008 ; Vol. 43, No. 6. pp. 421-426.
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AU - Kauczor, Hans Ulrich

AU - Szabó, G.

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