Abstract
OBJECTIVES: Phase-contrast flow magnetic resonance imaging (pc-MRI) measurements are an established technique for noninvasive assessment of hemodynamics. However, in vivo validation data on the accuracy of pc-flow especially for nonphysiologic hemodynamic conditions are missing. The goal of our work was 1) to validate pc-flow with perivascular ultrasound in different hemodynamic conditions in the main pulmonary artery (MPA) and ascending aorta (AO) and 2) to investigate the relation between pc-MRI and invasive pressure measurements. MATERIALS AND METHODS: Five healthy pigs with opened chest were investigated. Ultrasound measurements were performed outside the MRI unit using a detachable MR-table. Parallel to ultrasound flow measurements, invasive pressure measurements were performed. PC-MRI (1.5 T MRI) measurements were done using a FLASH 2-dimensional sequence. First the animals were examined in normotonia, followed by hypertension (infusion of Arterenol) and hypotension (infusion of Sodiumnitropussid). RESULTS: Flow measurements acquired in normotonia were 2.7 ± 0.6 L/min (ultrasound) and 2.8 ± 0.6 L/min for pc-MRI (not significantly different, P = 0.17). During hypertonia, the blood flow increased to 3.1 ± 0.7 and 2.7 ± 0.8 L/min, respectively (P = 0.01). During hypotension, the blood flow decreased to 1.7 ± 0.5 and 1.7 ± 0.5 L/min, respectively (P = 0.7). An excellent linear correlation (taking all measurements together) between the ultrasound and pc-MRI measurements was found (r = 0.89). 95% Limits of intraindividual agreement correspond to relative differences of -36 to 44%. Systolic pressure measurements in the AO were 91 mm Hg (normotonic), 111 mm Hg (hypertonic), and 64 mm Hg (hypotonic) and in the MPA 23 mm Hg (normotonic), 29 mm Hg (hypertonic), and 20 mm Hg (hypotonic). Systolic pressure measurements showed good linear correlation with pc-MRI average flow per minute and peak velocity (AO: r = 0.79, MPA: r = 0.66). CONCLUSION: MRI pc-flow measurements are a reliable tool for noninvasive assessment of blood flow. Hemodynamic parameters derived by MRI demonstrate good linear correlations with the pressure in the systemic and pulmonary arterial circulation.
| Original language | English |
|---|---|
| Pages (from-to) | 421-426 |
| Number of pages | 6 |
| Journal | Investigative Radiology |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Animal
- MRI
- Perivascular ultrasound
- Phase contrast flow
- Validation
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model. / Ley, Sebastian; Unterhinninghofen, Roland; Ley-Zaporozhan, Julia; Schenk, Jens Peter; Kauczor, Hans Ulrich; Szabó, G.
In: Investigative Radiology, Vol. 43, No. 6, 06.2008, p. 421-426.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of magnetic resonance phase-contrast flow measurements in the main pulmonary artery and aorta using perivascular ultrasound in a large animal model
AU - Ley, Sebastian
AU - Unterhinninghofen, Roland
AU - Ley-Zaporozhan, Julia
AU - Schenk, Jens Peter
AU - Kauczor, Hans Ulrich
AU - Szabó, G.
PY - 2008/6
Y1 - 2008/6
N2 - OBJECTIVES: Phase-contrast flow magnetic resonance imaging (pc-MRI) measurements are an established technique for noninvasive assessment of hemodynamics. However, in vivo validation data on the accuracy of pc-flow especially for nonphysiologic hemodynamic conditions are missing. The goal of our work was 1) to validate pc-flow with perivascular ultrasound in different hemodynamic conditions in the main pulmonary artery (MPA) and ascending aorta (AO) and 2) to investigate the relation between pc-MRI and invasive pressure measurements. MATERIALS AND METHODS: Five healthy pigs with opened chest were investigated. Ultrasound measurements were performed outside the MRI unit using a detachable MR-table. Parallel to ultrasound flow measurements, invasive pressure measurements were performed. PC-MRI (1.5 T MRI) measurements were done using a FLASH 2-dimensional sequence. First the animals were examined in normotonia, followed by hypertension (infusion of Arterenol) and hypotension (infusion of Sodiumnitropussid). RESULTS: Flow measurements acquired in normotonia were 2.7 ± 0.6 L/min (ultrasound) and 2.8 ± 0.6 L/min for pc-MRI (not significantly different, P = 0.17). During hypertonia, the blood flow increased to 3.1 ± 0.7 and 2.7 ± 0.8 L/min, respectively (P = 0.01). During hypotension, the blood flow decreased to 1.7 ± 0.5 and 1.7 ± 0.5 L/min, respectively (P = 0.7). An excellent linear correlation (taking all measurements together) between the ultrasound and pc-MRI measurements was found (r = 0.89). 95% Limits of intraindividual agreement correspond to relative differences of -36 to 44%. Systolic pressure measurements in the AO were 91 mm Hg (normotonic), 111 mm Hg (hypertonic), and 64 mm Hg (hypotonic) and in the MPA 23 mm Hg (normotonic), 29 mm Hg (hypertonic), and 20 mm Hg (hypotonic). Systolic pressure measurements showed good linear correlation with pc-MRI average flow per minute and peak velocity (AO: r = 0.79, MPA: r = 0.66). CONCLUSION: MRI pc-flow measurements are a reliable tool for noninvasive assessment of blood flow. Hemodynamic parameters derived by MRI demonstrate good linear correlations with the pressure in the systemic and pulmonary arterial circulation.
AB - OBJECTIVES: Phase-contrast flow magnetic resonance imaging (pc-MRI) measurements are an established technique for noninvasive assessment of hemodynamics. However, in vivo validation data on the accuracy of pc-flow especially for nonphysiologic hemodynamic conditions are missing. The goal of our work was 1) to validate pc-flow with perivascular ultrasound in different hemodynamic conditions in the main pulmonary artery (MPA) and ascending aorta (AO) and 2) to investigate the relation between pc-MRI and invasive pressure measurements. MATERIALS AND METHODS: Five healthy pigs with opened chest were investigated. Ultrasound measurements were performed outside the MRI unit using a detachable MR-table. Parallel to ultrasound flow measurements, invasive pressure measurements were performed. PC-MRI (1.5 T MRI) measurements were done using a FLASH 2-dimensional sequence. First the animals were examined in normotonia, followed by hypertension (infusion of Arterenol) and hypotension (infusion of Sodiumnitropussid). RESULTS: Flow measurements acquired in normotonia were 2.7 ± 0.6 L/min (ultrasound) and 2.8 ± 0.6 L/min for pc-MRI (not significantly different, P = 0.17). During hypertonia, the blood flow increased to 3.1 ± 0.7 and 2.7 ± 0.8 L/min, respectively (P = 0.01). During hypotension, the blood flow decreased to 1.7 ± 0.5 and 1.7 ± 0.5 L/min, respectively (P = 0.7). An excellent linear correlation (taking all measurements together) between the ultrasound and pc-MRI measurements was found (r = 0.89). 95% Limits of intraindividual agreement correspond to relative differences of -36 to 44%. Systolic pressure measurements in the AO were 91 mm Hg (normotonic), 111 mm Hg (hypertonic), and 64 mm Hg (hypotonic) and in the MPA 23 mm Hg (normotonic), 29 mm Hg (hypertonic), and 20 mm Hg (hypotonic). Systolic pressure measurements showed good linear correlation with pc-MRI average flow per minute and peak velocity (AO: r = 0.79, MPA: r = 0.66). CONCLUSION: MRI pc-flow measurements are a reliable tool for noninvasive assessment of blood flow. Hemodynamic parameters derived by MRI demonstrate good linear correlations with the pressure in the systemic and pulmonary arterial circulation.
KW - Animal
KW - MRI
KW - Perivascular ultrasound
KW - Phase contrast flow
KW - Validation
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UR - http://www.scopus.com/inward/citedby.url?scp=44449177471&partnerID=8YFLogxK
U2 - 10.1097/RLI.0b013e318169015d
DO - 10.1097/RLI.0b013e318169015d
M3 - Article
C2 - 18496047
AN - SCOPUS:44449177471
VL - 43
SP - 421
EP - 426
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 6
ER -