Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes

Tünde Molnár, J. Visy, A. Simon, István Moldvai, Eszter Temesvári-Major, Gábor Dörnyei, Erzsébet Kútiné Fekete, J. Kardos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [3H]-SUC or [3H]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype.

Original languageEnglish
Pages (from-to)6290-6292
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number23
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

Succinic Acid
Binding Sites
Synaptic Membranes
Citric Acid Cycle
Rats
Brain
Membranes
NCS 382
4-hydroxybutyric acid receptor
4-hydroxybutyric acid

Keywords

  • Gamma-hydroxybutyric acid (GHB)
  • NCS 382
  • Succinic acid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes. / Molnár, Tünde; Visy, J.; Simon, A.; Moldvai, István; Temesvári-Major, Eszter; Dörnyei, Gábor; Fekete, Erzsébet Kútiné; Kardos, J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 23, 01.12.2008, p. 6290-6292.

Research output: Contribution to journalArticle

Molnár, Tünde ; Visy, J. ; Simon, A. ; Moldvai, István ; Temesvári-Major, Eszter ; Dörnyei, Gábor ; Fekete, Erzsébet Kútiné ; Kardos, J. / Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 23. pp. 6290-6292.
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