Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes

Tünde Molnár, Júlia Visy, Ágnes Simon, István Moldvai, Eszter Temesvári-Major, Gábor Dörnyei, Erzsébet Kútiné Fekete, Julianna Kardos

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [3H]-SUC or [3H]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype.

Original languageEnglish
Pages (from-to)6290-6292
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number23
DOIs
Publication statusPublished - Dec 1 2008

Keywords

  • Gamma-hydroxybutyric acid (GHB)
  • NCS 382
  • Succinic acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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