Validation of a tentative microsatellite marker for the dopamine D4 receptor gene by capillary gel electrophoresis

Agnes Toth-Petroczy, Agnes Szilagyi, Zsolt Ronai, Maria Sasvari-Szekely, András Guttman

Research output: Contribution to journalArticle

Abstract

Two to four-basepair-short tandem repeats (i.e. microsatellites) are broadly utilized as genetic markers for mapping disease loci in whole genome search analyses. Based on their close vicinity on chromosome 11, the D11S1984 microsatellite was anticipated as a tentative marker for the dopamine D4 receptor gene. A capillary gel electrophoresis based genotype analysis method and an in-house made computational tool was developed for the analysis of the D11S1984 microsatellite marker to examine a healthy Hungarian population of n = 106. The data obtained did not suggest significant linkage between the D11S1984 marker and the DRD4 gene.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalJournal of Chromatography A
Volume1130
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - Oct 20 2006

Keywords

  • Capillary electrophoresis
  • Linkage disequilibrium
  • Microsatellite
  • Variable number of tandem repeats

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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