Vagus nerve stimulation

Predictors of seizure freedom

J. Janszky, M. Hoppe, F. Behne, I. Tuxhorn, H. W. Pannek, Alois Ebner

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objectives: To identify predictive factors for the seizure-free outcome of vagus nerve stimulation (VNS). Methods: All 47 patients who had undergone VNS implantation at one centre and had at least one year of follow up were studied. They underwent complete presurgical evaluation including detailed clinical history, magnetic resonance imaging, and long term video-EEG with ictal and interictal recordings. After implantation, adjustment of stimulation parameters and concomitant antiepileptic drugs were at the discretion of the treating physician. Results: Mean (SD) age of the patients was 22.7 (11.6) years (range 7 to 53). Six patients (13%) became seizure-free after the VNS implantation. Only two variables showed a significant association with the seizure-free outcome: absence of bilateral interictal epileptiform discharges (IED) and presence of malformation of cortical development (MCD). Epilepsy duration showed a non-significant trend towards a negative association with outcome. By logistic regression analysis, only absence of bilateral IED correlated independently with successful VNS treatment (p

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume76
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Vagus Nerve Stimulation
Seizures
Malformations of Cortical Development
Anticonvulsants
Electroencephalography
Epilepsy
Logistic Models
Stroke
Regression Analysis
Magnetic Resonance Imaging
Physicians

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Vagus nerve stimulation : Predictors of seizure freedom. / Janszky, J.; Hoppe, M.; Behne, F.; Tuxhorn, I.; Pannek, H. W.; Ebner, Alois.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 76, No. 3, 03.2005, p. 384-389.

Research output: Contribution to journalArticle

Janszky, J. ; Hoppe, M. ; Behne, F. ; Tuxhorn, I. ; Pannek, H. W. ; Ebner, Alois. / Vagus nerve stimulation : Predictors of seizure freedom. In: Journal of Neurology, Neurosurgery and Psychiatry. 2005 ; Vol. 76, No. 3. pp. 384-389.
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