Vaginal gel component hydroxyethyl cellulose significantly enhances the infectivity of chlamydia trachomatis serovars D and E

Tímea Raffai, K. Burián, László Janovák, Anita Bogdanov, Johannes H. Hegemann, V. Endrész, D. Virók

Research output: Contribution to journalArticle

Abstract

The transmission of the urogenital serovars of Chlamydia trachomatis can be significantly influenced by vaginal gels. Hydroxyethyl cellulose is a commonly used gelling agent that can be found in vaginal gels. Hydroxyethyl cellulose showed a concentration-dependent growth-enhancing effect on C. trachomatis serovars D and E, with a 26.1-fold maximal increase in vitro and a 2.57-fold increase in vivo.

Original languageEnglish
Article numbere02034-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Foams and Jellies Vaginal Creams
Chlamydia trachomatis
Cellulose
Growth
Serogroup
In Vitro Techniques

Keywords

  • Chlamydia trachomatis
  • Hydroxyethyl cellulose
  • Infectivity
  • Vaginal gel

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Vaginal gel component hydroxyethyl cellulose significantly enhances the infectivity of chlamydia trachomatis serovars D and E. / Raffai, Tímea; Burián, K.; Janovák, László; Bogdanov, Anita; Hegemann, Johannes H.; Endrész, V.; Virók, D.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 1, e02034-18, 01.01.2019.

Research output: Contribution to journalArticle

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