Vaginal gel component hydroxyethyl cellulose significantly enhances the infectivity of chlamydia trachomatis serovars D and E

Tímea Raffai, Katalin Burián, László Janovák, Anita Bogdanov, Johannes H. Hegemann, Valéria Endrész, Dezso P. Virok

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3 Citations (Scopus)

Abstract

The transmission of the urogenital serovars of Chlamydia trachomatis can be significantly influenced by vaginal gels. Hydroxyethyl cellulose is a commonly used gelling agent that can be found in vaginal gels. Hydroxyethyl cellulose showed a concentration-dependent growth-enhancing effect on C. trachomatis serovars D and E, with a 26.1-fold maximal increase in vitro and a 2.57-fold increase in vivo.

Original languageEnglish
Article numbere02034-18
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 2019

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Keywords

  • Chlamydia trachomatis
  • Hydroxyethyl cellulose
  • Infectivity
  • Vaginal gel

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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