Vaccines for type 1 diabetes

William H R Langridge, Oludare J. Odumosu, B. Dénes, István Fodor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Juvenile onset type 1 diabetes is a life-long, incurable, progressive autoimmune disease that is increasing throughout the world at an alarming rate. Insulin injection is the only known substantially effective therapy which has the risk of complications leading to a significant reduction in life expectancy. While many individual therapies provide partial protection against development of autoimmune diabetes, more recently developed multicomponent vaccine strategies hold promise for halting diabetes progression restoring euglycemia and providing a more durable immunological homeostasis. In this chapter, we examine mechanisms underlying the onset and development of type 1 diabetes and assess individual and multicomponent immunosuppression strategies including edible plant and virus delivery of immunostimulated diabetes autoantigens and anti-inflammatory cytokines. Identification of mechanisms underlying interactions between combinatorial vaccine components and the host immune system will establish a basis for construction of safer, more effective and durable forms of immunotherapy for patients at risk or suffering from this life-long chronic inflammatory disease.

Original languageEnglish
Title of host publicationHandbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment
PublisherNova Science Publishers, Inc.
Pages207-236
Number of pages30
ISBN (Print)9781607413110
Publication statusPublished - 2010

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Type 1 Diabetes Mellitus
Vaccines
Plant Viruses
Edible Plants
Autoantigens
Life Expectancy
Immunotherapy
Immunosuppression
Autoimmune Diseases
Immune System
Homeostasis
Chronic Disease
Anti-Inflammatory Agents
Insulin
Cytokines
Injections
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Langridge, W. H. R., Odumosu, O. J., Dénes, B., & Fodor, I. (2010). Vaccines for type 1 diabetes. In Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment (pp. 207-236). Nova Science Publishers, Inc..

Vaccines for type 1 diabetes. / Langridge, William H R; Odumosu, Oludare J.; Dénes, B.; Fodor, István.

Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc., 2010. p. 207-236.

Research output: Chapter in Book/Report/Conference proceedingChapter

Langridge, WHR, Odumosu, OJ, Dénes, B & Fodor, I 2010, Vaccines for type 1 diabetes. in Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc., pp. 207-236.
Langridge WHR, Odumosu OJ, Dénes B, Fodor I. Vaccines for type 1 diabetes. In Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc. 2010. p. 207-236
Langridge, William H R ; Odumosu, Oludare J. ; Dénes, B. ; Fodor, István. / Vaccines for type 1 diabetes. Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc., 2010. pp. 207-236
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