V-chain preference of gamma/delta T-cell receptors in peripheral blood during term labor

A. Barakonyi, Eva Miko, Peter Varga, J. Szekeres-Barthó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Problem: An altered function of the maternal immune system creates a favorable environment for the developing fetus during pregnancy. At term, new regulatory mechanisms are activated, to initiate labor. Earlier we showed that in peripheral blood of pregnant women gamma/delta T cells of cytotoxic phenotype are replaced by those of a non-cytotoxic phenotype. Here we studied the Vgamma and Vdelta chain usage of peripheral gamma/delta T cells from women in labor. Methods of study: Vgamma and Vdelta chain expression on peripheral blood lymphocytes obtained at the 3rd trimester of pregnancy and during parturition were examined by immuncytochemistry and flow cytometry. Results: Increased % of Vgamma9/Vdelta2 and decreased % of Vgamma4/ Vdelta1 T cells were found in peripheral blood during labor, together with unaltered percentages of single Vgamma+ or Vdelta+ cells. The initially high Vgamma4/Vdelta1 to Vgamma9/Vdelta2 ratio decreased during labor. Conclusion: The initiation of labor is characterized by an altered V-chain usage of gamma/delta T cells.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume59
Issue number3
DOIs
Publication statusPublished - Mar 2008

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Antigen Receptors, T-Cell, gamma-delta
Somatostatin-Secreting Cells
T-Lymphocytes
Pregnancy Trimesters
Phenotype
Pregnant Women
Immune System
Flow Cytometry
Fetus
Mothers
Parturition
Lymphocytes
Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

V-chain preference of gamma/delta T-cell receptors in peripheral blood during term labor. / Barakonyi, A.; Miko, Eva; Varga, Peter; Szekeres-Barthó, J.

In: American Journal of Reproductive Immunology, Vol. 59, No. 3, 03.2008, p. 201-205.

Research output: Contribution to journalArticle

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abstract = "Problem: An altered function of the maternal immune system creates a favorable environment for the developing fetus during pregnancy. At term, new regulatory mechanisms are activated, to initiate labor. Earlier we showed that in peripheral blood of pregnant women gamma/delta T cells of cytotoxic phenotype are replaced by those of a non-cytotoxic phenotype. Here we studied the Vgamma and Vdelta chain usage of peripheral gamma/delta T cells from women in labor. Methods of study: Vgamma and Vdelta chain expression on peripheral blood lymphocytes obtained at the 3rd trimester of pregnancy and during parturition were examined by immuncytochemistry and flow cytometry. Results: Increased {\%} of Vgamma9/Vdelta2 and decreased {\%} of Vgamma4/ Vdelta1 T cells were found in peripheral blood during labor, together with unaltered percentages of single Vgamma+ or Vdelta+ cells. The initially high Vgamma4/Vdelta1 to Vgamma9/Vdelta2 ratio decreased during labor. Conclusion: The initiation of labor is characterized by an altered V-chain usage of gamma/delta T cells.",
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AB - Problem: An altered function of the maternal immune system creates a favorable environment for the developing fetus during pregnancy. At term, new regulatory mechanisms are activated, to initiate labor. Earlier we showed that in peripheral blood of pregnant women gamma/delta T cells of cytotoxic phenotype are replaced by those of a non-cytotoxic phenotype. Here we studied the Vgamma and Vdelta chain usage of peripheral gamma/delta T cells from women in labor. Methods of study: Vgamma and Vdelta chain expression on peripheral blood lymphocytes obtained at the 3rd trimester of pregnancy and during parturition were examined by immuncytochemistry and flow cytometry. Results: Increased % of Vgamma9/Vdelta2 and decreased % of Vgamma4/ Vdelta1 T cells were found in peripheral blood during labor, together with unaltered percentages of single Vgamma+ or Vdelta+ cells. The initially high Vgamma4/Vdelta1 to Vgamma9/Vdelta2 ratio decreased during labor. Conclusion: The initiation of labor is characterized by an altered V-chain usage of gamma/delta T cells.

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