UV light induced photodegradation of liposome encapsulated fluoroquinolones: An MS study

Marianna Budai, Pál Gróf, Andreas Zimmer, Katalin Pápai, Imre Klebovich, Krisztina Ludányi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Fluoroquinolone antibacterial agents are among the drugs most commonly causing phototoxic side effects. The phototoxicity may be originated in formation of reactive oxygen species upon ultraviolet exposure. Researches aiming the liposomal encapsulation of fluoroquinolones, expecting an increase in their therapeutic index, enhance the importance of studies on physicochemical properties and photostability of liposomal preparations. We studied the photodegradation of ciprofloxacin, ofloxacin and lomefloxacin by mass spectrometry upon various doses of UV irradiation. Lomefloxacin, the most phototoxic fluoroquinolone among them, was encapsulated into small unilamellar and multilamellar liposomes. Impact of vesicle structure and lipid composition - the presence of unsaturated fatty acid containing dioleoyl-phosphatidylcholine in dipalmitoyl-phosphatidylcholine liposomes - on the lomefloxacin photolysis was investigated; the structure of the main photoproducts was identified by mass spectrometry. It was found that the presence and type of lipids influence the ways of photodegradation process.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume198
Issue number2-3
DOIs
Publication statusPublished - Aug 15 2008

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Keywords

  • Fluoroquinolone
  • Liposome
  • Mass spectrometry
  • Photodegradation
  • UV

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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