Szuperfúziós technika alkalmazása a myometriális adrenerg transzmisszió vizsgálatára

Translated title of the contribution: Utilization of superfusion technique for the investigation of myometrial adrenergic transmission

Csonka Dénes, Kormányos Zsolt, Csík Gábor, Zupkó Isrván, G. Falkay

Research output: Contribution to journalArticle

Abstract

Adrenergic system is one of the crucial factors determining the contractility of the pregnant myometrium. However, results concerning the functional changing of the system as a consequence of pregnancy or pharmacological intervention are limited. The aim of the present study was application of superfusion technique for the functional investigation of myometrial adrenergic transmission. Uterine samples from virgo and early pregnant control or α-methyldopa-treated rats as well as tissues from patients of different hormonal states were saturated with [3H] noradrenaline and then the uptake capacity and the electrically-evoked release were determined. Pregnancy-induced adrenergic denervation can be detected earlier by superfusion than histochemical methods. Treatment with α-methyldopa increased the functional deterioration of the adrenergic fibers. Postmenopausal status decreased transmitter uptake and release compared to regular menstruation. It is concluded that superfusion is suitable and reliable tool for functional investigation of myometrial adrenergic transmission.

Original languageHungarian
Pages (from-to)121-126
Number of pages6
JournalMagyar Noorvosok Lapja
Volume71
Issue number3
Publication statusPublished - 2008

Fingerprint

Adrenergic Agents
Methyldopa
Adrenergic Fibers
Pregnancy
Menstruation
Myometrium
Denervation
Norepinephrine
Pharmacology
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Szuperfúziós technika alkalmazása a myometriális adrenerg transzmisszió vizsgálatára. / Dénes, Csonka; Zsolt, Kormányos; Gábor, Csík; Isrván, Zupkó; Falkay, G.

In: Magyar Noorvosok Lapja, Vol. 71, No. 3, 2008, p. 121-126.

Research output: Contribution to journalArticle

Dénes, Csonka ; Zsolt, Kormányos ; Gábor, Csík ; Isrván, Zupkó ; Falkay, G. / Szuperfúziós technika alkalmazása a myometriális adrenerg transzmisszió vizsgálatára. In: Magyar Noorvosok Lapja. 2008 ; Vol. 71, No. 3. pp. 121-126.
@article{e1b5f515d52f4c8396b05391d2be0e37,
title = "Szuperf{\'u}zi{\'o}s technika alkalmaz{\'a}sa a myometri{\'a}lis adrenerg transzmisszi{\'o} vizsg{\'a}lat{\'a}ra",
abstract = "Adrenergic system is one of the crucial factors determining the contractility of the pregnant myometrium. However, results concerning the functional changing of the system as a consequence of pregnancy or pharmacological intervention are limited. The aim of the present study was application of superfusion technique for the functional investigation of myometrial adrenergic transmission. Uterine samples from virgo and early pregnant control or α-methyldopa-treated rats as well as tissues from patients of different hormonal states were saturated with [3H] noradrenaline and then the uptake capacity and the electrically-evoked release were determined. Pregnancy-induced adrenergic denervation can be detected earlier by superfusion than histochemical methods. Treatment with α-methyldopa increased the functional deterioration of the adrenergic fibers. Postmenopausal status decreased transmitter uptake and release compared to regular menstruation. It is concluded that superfusion is suitable and reliable tool for functional investigation of myometrial adrenergic transmission.",
keywords = "α-methyldopa, Adrenergic system, Denervation, Myometrium, Superfusion",
author = "Csonka D{\'e}nes and Korm{\'a}nyos Zsolt and Cs{\'i}k G{\'a}bor and Zupk{\'o} Isrv{\'a}n and G. Falkay",
year = "2008",
language = "Hungarian",
volume = "71",
pages = "121--126",
journal = "Magyar Noorvosok Lapja",
issn = "0025-021X",
publisher = "Magyar Noovos Tarsasag",
number = "3",

}

TY - JOUR

T1 - Szuperfúziós technika alkalmazása a myometriális adrenerg transzmisszió vizsgálatára

AU - Dénes, Csonka

AU - Zsolt, Kormányos

AU - Gábor, Csík

AU - Isrván, Zupkó

AU - Falkay, G.

PY - 2008

Y1 - 2008

N2 - Adrenergic system is one of the crucial factors determining the contractility of the pregnant myometrium. However, results concerning the functional changing of the system as a consequence of pregnancy or pharmacological intervention are limited. The aim of the present study was application of superfusion technique for the functional investigation of myometrial adrenergic transmission. Uterine samples from virgo and early pregnant control or α-methyldopa-treated rats as well as tissues from patients of different hormonal states were saturated with [3H] noradrenaline and then the uptake capacity and the electrically-evoked release were determined. Pregnancy-induced adrenergic denervation can be detected earlier by superfusion than histochemical methods. Treatment with α-methyldopa increased the functional deterioration of the adrenergic fibers. Postmenopausal status decreased transmitter uptake and release compared to regular menstruation. It is concluded that superfusion is suitable and reliable tool for functional investigation of myometrial adrenergic transmission.

AB - Adrenergic system is one of the crucial factors determining the contractility of the pregnant myometrium. However, results concerning the functional changing of the system as a consequence of pregnancy or pharmacological intervention are limited. The aim of the present study was application of superfusion technique for the functional investigation of myometrial adrenergic transmission. Uterine samples from virgo and early pregnant control or α-methyldopa-treated rats as well as tissues from patients of different hormonal states were saturated with [3H] noradrenaline and then the uptake capacity and the electrically-evoked release were determined. Pregnancy-induced adrenergic denervation can be detected earlier by superfusion than histochemical methods. Treatment with α-methyldopa increased the functional deterioration of the adrenergic fibers. Postmenopausal status decreased transmitter uptake and release compared to regular menstruation. It is concluded that superfusion is suitable and reliable tool for functional investigation of myometrial adrenergic transmission.

KW - α-methyldopa

KW - Adrenergic system

KW - Denervation

KW - Myometrium

KW - Superfusion

UR - http://www.scopus.com/inward/record.url?scp=49949112568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49949112568&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:49949112568

VL - 71

SP - 121

EP - 126

JO - Magyar Noorvosok Lapja

JF - Magyar Noorvosok Lapja

SN - 0025-021X

IS - 3

ER -