Utility of cyclodextrins in the formulation of genistein. Part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins

Ágnes Emma Daruházi, Lajos Szente, Balázs Balogh, Péter Mátyus, Szabolcs Béni, Mária Takács, András Gergely, Péter Horváth, Éva Szoke, Éva Lemberkovics

Research output: Contribution to journalArticle

35 Citations (Scopus)


Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both β-cyclodextrin (β-CD) and γ-cyclodextrin (γ-CD), while it did not form a stable complex with α-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both β- and γ-CD, significantly surpassed that of the plain isoflavone.

Original languageEnglish
Pages (from-to)636-640
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Issue number3
Publication statusPublished - Nov 4 2008



  • Circular dichroism
  • Genistein
  • Ononis
  • Parent cyclodextrins
  • Solubility

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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