Uterine leiomyosarcoma with osteoclast like giant cells and long standing systemic symptoms

Kalman Patai, Gyorgy Illyes, Szabolcs Varbiro, Janos Gidai, Lajos Kosa, Zoltan Vajo

Research output: Contribution to journalArticle

13 Citations (Scopus)


Introduction.: The leiomyomatous type of uterine sarcoma with osteoclast-type giant cell component is a rare variant of uterine tumors with poor prognosis. The histological diagnosis of these rare tumors can be problematic and only five such tumors have been published previously. Case Report.: A 54-year-old woman presented with fever and weight loss for 7 months and laboratory findings suggestive of inflammation. After extensive clinical investigation, a uterine tumor was found, which was considered to be an incidental finding and was thought to be unlikely to explain the symptoms. After hysterectomy, the patient had a surprising and quick recovery with the complete relief of systemic symptoms and normalization of laboratory changes. The tumor was a dedifferentiated leiomyosarcoma with osteoclast-like giant cells and contained extensive necrosis. The patient continues to do well and is tumor-free 1 year after the operation. Discussion.: To our knowledge, this is the first report of a patient being alive and disease-free 12 months after surgery with a dedifferentiated uterine leiomyosarcoma with osteoclast-like giant cells.

Original languageEnglish
Pages (from-to)403-405
Number of pages3
JournalGynecologic Oncology
Issue number2
Publication statusPublished - Aug 1 2006



  • Immunohistochemistry
  • Leiomyosarcoma
  • Osteoclast-like giant cells
  • Uterus

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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