Using low-frequency oscillation to detect bronchodilator responsiveness in infants

Mark J. Hayden, F. Peták, Z. Hantos, Graham Hall, Peter D. Sly

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p <0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.

Original languageEnglish
Pages (from-to)574-579
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume157
Issue number2
Publication statusPublished - 1998

Fingerprint

Bronchodilator Agents
Albuterol
Airway Resistance
Placebos
Aerosols
Electric Impedance
Respiratory System
Reflex
Respiration
Metals
Pressure
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Using low-frequency oscillation to detect bronchodilator responsiveness in infants. / Hayden, Mark J.; Peták, F.; Hantos, Z.; Hall, Graham; Sly, Peter D.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 157, No. 2, 1998, p. 574-579.

Research output: Contribution to journalArticle

@article{14609a3b384144e7b45bc7bad72feddb,
title = "Using low-frequency oscillation to detect bronchodilator responsiveness in infants",
abstract = "The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13{\%} for the entire group) occurred following treatment with salbutamol (p <0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65{\%} ± 5.49{\%}) and those with recurrent wheeze (17.58{\%} ± 8.67{\%}). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.",
author = "Hayden, {Mark J.} and F. Pet{\'a}k and Z. Hantos and Graham Hall and Sly, {Peter D.}",
year = "1998",
language = "English",
volume = "157",
pages = "574--579",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "2",

}

TY - JOUR

T1 - Using low-frequency oscillation to detect bronchodilator responsiveness in infants

AU - Hayden, Mark J.

AU - Peták, F.

AU - Hantos, Z.

AU - Hall, Graham

AU - Sly, Peter D.

PY - 1998

Y1 - 1998

N2 - The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p <0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.

AB - The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p <0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.

UR - http://www.scopus.com/inward/record.url?scp=0031913083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031913083&partnerID=8YFLogxK

M3 - Article

VL - 157

SP - 574

EP - 579

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 2

ER -