Using low-frequency oscillation to detect bronchodilator responsiveness in infants

Mark J. Hayden, Ferenc Petak, Zoltan Hantos, Graham Hall, Peter D. Sly

Research output: Contribution to journalArticle

28 Citations (Scopus)


The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p < 0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.

Original languageEnglish
Pages (from-to)574-579
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number2
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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