Using a mathematical model for diastolic filling through the mitral valve to determine cardiac properties

Jeremiah Wolfe, Gabor Szabo, Tamás Radovits, Lee Waite

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The current paper uses a computer model of early diastolic filling through the mitral valve, implemented in MATLAB, to find representative values for specific parameters used to define the model. The model is a lumped parameter model configured such that a velocity waveform, obtained from a patient's echocardiogram, serves as its primary input and the correspondingly predicted left atrial and left ventricular pressure waveforms are the primary outputs. Values were found for the following parameters: atrial and ventricular stiffness (α a and α v); active-relaxation characteristics, including time constant for isovolumetric pressure decay (T d0) and pressure decay constant (P d0); valve natural frequency (ω), and damping coefficient (D). Pre-operative (pre-op) and post-operative (post-op) data were used to find corresponding pre-op and post-op values for each of the parameters. A sequential Bonferroni correction technique applied after an unpaired two-sample t-test yielded no statistical difference between pre-op and post-op values for any of the parameters; however, the results are limited by small sample size.

Original languageEnglish
Title of host publication49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium
Pages113-120
Number of pages8
Publication statusPublished - Aug 20 2012
Event49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium - Blacksburg, VA, United States
Duration: Mar 22 2012Mar 24 2012

Publication series

Name49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium

Other

Other49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium
CountryUnited States
CityBlacksburg, VA
Period3/22/123/24/12

Keywords

  • Early diastolic filling
  • Lumped-parameter model
  • Mitral valve
  • Pressure
  • Stiffness

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Wolfe, J., Szabo, G., Radovits, T., & Waite, L. (2012). Using a mathematical model for diastolic filling through the mitral valve to determine cardiac properties. In 49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium (pp. 113-120). (49th Annual Rocky Mountain Bioengineering Symposium and 49th International ISA Biomedical Sciences Instrumentation Symposium).