Hasznos tesztek az új prognosztikai markerek klinikai értékének felmérésére

A szívelégtelenség példája

Translated title of the contribution: Useful tests to assess the clinical usefulness of new prognostic markers: The example of heart failure

Zsigmond Máté Jenei, Z. Prohászka

Research output: Contribution to journalArticle

Abstract

Introduction: Identification of risk factors is one of the most frequent questions in medical research currently. Several reports showed "significant" and "independent" prognostic factors in a variety of human conditions, however, those were not tested about predictive information in addition to standard risk markers. Recently novel statistical approaches (reclassification) have been developed to test the performance and usefulness of new risk factors and prognostic markers. There are several established methods to test the prognostic models. Aim: The aim of this work was to present the application of these novel statistical approaches by re-analyzing previously reported results of the authors. Method: The authors analyzed the prognostic role of two markers: red cell distribution width and heat shock protein 70 in patients with heart failure. Using Cox regression analyses the authors have reported previously that both markers are independent predictors. In the present study they re-analyzed the role of red cell distribution width and heat shock protein 70 by reclassification tests. Results: Incorporating red cell distribution width to the reference model the authors found a significant improvement in discrimination . However, the reclassification analysis provided ambiguous results with heat shock protein 70. Conclusions: Interpretation of results on new prognostic factors has to be done carefully, and appropriate reclassification approaches may help to confirm clinical usefulness only.

Original languageHungarian
Pages (from-to)1374-1380
Number of pages7
JournalOrvosi Hetilap
Volume154
Issue number35
DOIs
Publication statusPublished - Sep 1 2013

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HSP70 Heat-Shock Proteins
Erythrocyte Indices
Heart Failure
Biomedical Research
Regression Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hasznos tesztek az új prognosztikai markerek klinikai értékének felmérésére : A szívelégtelenség példája. / Jenei, Zsigmond Máté; Prohászka, Z.

In: Orvosi Hetilap, Vol. 154, No. 35, 01.09.2013, p. 1374-1380.

Research output: Contribution to journalArticle

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