Use of thermoplastic starch in continuous pharmaceutical proces

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Controlled release formulations of thermoplastic starch (TPS) matrix were prepared by extrusion granulation and injection molding of tablets. The compositions contained glycerol, water and on occasion urea plasticizers, glycerol-monostearate; Ca-stearate lubricants and Na-benzoate drug representing component, in addition to the starch. The lubricants and especially the urea reduce the complex viscosity of the TPS considerably facilitating the injection molding process-ability. DSC thermal analysis demonstrated, the urea is in a molecular dispersed form in the extruded granules and Raman microscopic mapping showed an under micron sized dispersion of Na-benzoate in injection molded tablets. Both the extrusion and the injection molding processing resulted retard release character of the active component.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalMacromolecular Symposia
Volume239
DOIs
Publication statusPublished - 2006

Fingerprint

injection molding
starches
Starch
ureas
Injection molding
Urea
Drug products
Thermoplastics
tablets
Benzoates
lubricants
glycerols
Glycerol
Tablets
Extrusion
Lubricants
Pharmaceutical Preparations
Stearates
Plasticizers
stearates

Keywords

  • Controlled release
  • Drug formulation
  • Extrusion
  • Injection molding
  • Raman microscopy
  • Thermoplastic starch

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Use of thermoplastic starch in continuous pharmaceutical proces. / Keszei, S.; Szabó, A.; Marosi, G.; Anna, P.; Nagy, Sándor.

In: Macromolecular Symposia, Vol. 239, 2006, p. 101-104.

Research output: Contribution to journalArticle

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AU - Nagy, Sándor

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