Use of the equilibrium-dispersive model of nonlinear gas chromatography for the modelling of the elution band profiles in the preparative-scale gas chromatographic separation of enantiomers

Daniel U. Staerk, Aroonsiri Shitangkoon, Eileen Winchester, Gyula Vigh, Attila Felinger, Georges Guiochon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The equilibrium-dispersive model of chromatography is applied to the study of enantioselective separations of methyl 2-chloropropionate in gas chromatography. The single-component and competitive bi-Langmuir isotherm equations that describe the sorption behavior of single enantiomers and racemates, respectively, are utilized by the equilibrium-dispersive model to predict the elution band profiles of single-component and binary mixture samples. The measured and the calculated band profiles are compared both for the analytical open tubular column used to acquire the isotherm data and for the 1 m x 22.5 mm I.D. preparative packed column, followed by the comparison of the enantiomeric purity vs. production curves for both the measured and the simulated systems.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalJournal of Chromatography A
Volume734
Issue number2
DOIs
Publication statusPublished - May 24 1996

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Keywords

  • Adsorption isotherms
  • Band profiles
  • Enantiomer separation
  • Equilibrium dispersive model
  • Methyl chloropropionate
  • Nonlinear chromatograpy
  • Preparative chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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