Use of spectral mapping technique for the evaluation of the formation of inclusion complexes between anticancer drugs and cyclodextrin derivatives

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Spectral mapping technique has been used for the separation of the strength and selectivity of the relative strength of interaction between 18 commercial anticancer drugs and 7 cyclodextrin derivatives. The potency values of the spectral map was considered as indicators of the capacity of anticancer drugs and cyclodextrins to interact with each other taking all the data into consideration simultaneously. The multidimensional selectivity map was visualized by the two-dimensional nonlinear mapping technique, the iterations was carded out to the point when the difference between the last two iterations was lower than 10-8. It has been established that both the diameter of the cyclodextrin cavity and the number and type of substituents on outer sphere of the cyclodextrin molecules influence the complex forming capacity.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalChemometrics and Intelligent Laboratory Systems
Volume40
Issue number1
DOIs
Publication statusPublished - May 1998

Fingerprint

Cyclodextrins
Drugs
Inclusion
Selectivity
Derivatives
Derivative
Evaluation
Pharmaceutical Preparations
Iteration
Nonlinear Mapping
Cavity
Molecules
Interaction

Keywords

  • Anticancer drugs
  • Complex formation
  • Cyclodextrin derivatives
  • Spectral mapping

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Statistics and Probability

Cite this

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AB - Spectral mapping technique has been used for the separation of the strength and selectivity of the relative strength of interaction between 18 commercial anticancer drugs and 7 cyclodextrin derivatives. The potency values of the spectral map was considered as indicators of the capacity of anticancer drugs and cyclodextrins to interact with each other taking all the data into consideration simultaneously. The multidimensional selectivity map was visualized by the two-dimensional nonlinear mapping technique, the iterations was carded out to the point when the difference between the last two iterations was lower than 10-8. It has been established that both the diameter of the cyclodextrin cavity and the number and type of substituents on outer sphere of the cyclodextrin molecules influence the complex forming capacity.

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