Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies

Erik Hauzman, Péter Fedorcsák, Klaus Klinga, Z. Papp, Thomas Rabe, Thomas Strowitzki, J. Urbancsek

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To assess the clinical value of maternal serum inhibin A measurements in early pregnancy in the prediction of outcome of IVF pregnancies and to compare the predictive accuracy of inhibin A concentrations with serum hCG concentrations. Design: Retrospective study. Setting: University-based IVF program. Patient(s): One hundred fifty IVF pregnancies of 150 couples were studied during a 4-year period. Intervention(s): None. Main outcome measure(s): The association between pregnancy outcome and age, number of collected oocytes, number of transferred embryos, and serum hCG and inhibin A concentrations in early pregnancy was studied with logistic regression. Predictive accuracy of inhibin A and hCG concentrations was calculated by receiver-operating characteristic (ROC) analysis. Result(s): Lower serum concentrations of inhibin A and hCG were associated with increased odds for preclinical abortion and early pregnancy loss, whereas higher inhibin A and hCG concentrations were observed in multiple ongoing pregnancies. Inhibin A measurements were superior to hCG in the prediction of preclinical abortions; no significant difference was observed between the predictive value of hCG, inhibin A, or their combination in differentiating between ongoing pregnancies and early pregnancy losses. The discriminative potential of inhibin A for prognosticating multiple ongoing pregnancies was lower than that of hCG. Conclusion(s): Although serum inhibin A concentrations are more accurate than hCG levels for predicting preclinical abortion after IVF, they had no advantage in forecasting ongoing or multiple ongoing pregnancies, suggesting that routine assessment of serum inhibin A concentrations during follow-up of IVF pregnancies is unjustified.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalFertility and Sterility
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Chorionic Gonadotropin
Fertilization in Vitro
Pregnancy
Serum
Multiple Pregnancy
Pregnancy Outcome
inhibin A
ROC Curve
Oocytes
Embryonic Structures
Retrospective Studies
Logistic Models
Mothers
Outcome Assessment (Health Care)

Keywords

  • hCG
  • In vitro fertilization
  • Inhibin A
  • Pregnancy outcome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies. / Hauzman, Erik; Fedorcsák, Péter; Klinga, Klaus; Papp, Z.; Rabe, Thomas; Strowitzki, Thomas; Urbancsek, J.

In: Fertility and Sterility, Vol. 81, No. 1, 01.2004, p. 66-72.

Research output: Contribution to journalArticle

Hauzman, Erik ; Fedorcsák, Péter ; Klinga, Klaus ; Papp, Z. ; Rabe, Thomas ; Strowitzki, Thomas ; Urbancsek, J. / Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies. In: Fertility and Sterility. 2004 ; Vol. 81, No. 1. pp. 66-72.
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