Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke

Crystal L. MacLellan, D. Clark, Gergely Silasi, Frederick Colbourne

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Therapeutic (induced) hypothermia (TH) has been extensively studied as a means to reduce brain injury following global and focal cerebral ischemia, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). Here, we briefly review the clinical and experimental evidence supporting the use of TH in each condition. We emphasize the importance of systematically evaluating treatment parameters, especially the duration of cooling, in each condition. We contend that TH provides considerable protection after global and focal cerebral ischemia, especially when cooling is prolonged (e.g., >24 h). However, there is presently insufficient evidence to support the clinical use of TH for ICH and SAH. In any case, further animal work is needed to develop optimized protocols for treating cardiac arrest (global ischemia), and to maximize the likelihood of successful clinical translation in focal cerebral ischemia.

Original languageEnglish
Pages (from-to)313-323
Number of pages11
JournalJournal of Neurotrauma
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

Hypothermia
Brain Ischemia
Induced Hypothermia
Stroke
Cerebral Hemorrhage
Subarachnoid Hemorrhage
Heart Arrest
Brain Injuries
Ischemia
Therapeutics

Keywords

  • Cardiac arrest
  • Rodent models
  • Stroke
  • Temperature
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke. / MacLellan, Crystal L.; Clark, D.; Silasi, Gergely; Colbourne, Frederick.

In: Journal of Neurotrauma, Vol. 26, No. 3, 01.03.2009, p. 313-323.

Research output: Contribution to journalArticle

MacLellan, Crystal L. ; Clark, D. ; Silasi, Gergely ; Colbourne, Frederick. / Use of prolonged hypothermia to treat ischemic and hemorrhagic stroke. In: Journal of Neurotrauma. 2009 ; Vol. 26, No. 3. pp. 313-323.
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